Codeine and Cholelithiasis - a phase IV clinical study of FDA data

Summary:

Cholelithiasis is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Synthroid, and have Crohn's disease.

The phase IV clinical study analyzes which people have Cholelithiasis when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Cholelithiasis?

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts) is found to be associated with 2,725 drugs and 2,075 conditions by eHealthMe. Check the latest studies of Cholelithiasis.

On Oct, 12, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 124 people (0.3%) have Cholelithiasis.

Among these 124 people:

How long have people been on Codeine when they have Cholelithiasis? *

What is the gender of people who have Cholelithiasis when taking Codeine? *

female: 70.69 %
male: 29.31 %

What is the age of people who have Cholelithiasis when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Cholelithiasis? *

Diarrhea: 60 people, 48.39%
Abdominal Pain: 59 people, 47.58%
Malaise (a feeling of general discomfort or uneasiness): 51 people, 41.13%
Fatigue (feeling of tiredness): 43 people, 34.68%
Stress And Anxiety: 40 people, 32.26%
Body Temperature Decreased: 39 people, 31.45%
Nausea (feeling of having an urge to vomit): 38 people, 30.65%
Pain In Extremity: 38 people, 30.65%
High Blood Pressure: 38 people, 30.65%
Weakness: 38 people, 30.65%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 18 people, 14.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 14 people, 11.29%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 14 people, 11.29%
Carcinoid Tumor Of The Small Bowel: 13 people, 10.48%
High Blood Pressure: 12 people, 9.68%
Depression: 11 people, 8.87%
Pituitary Tumor: 11 people, 8.87%
Constipation: 8 people, 6.45%
Headache (pain in head): 8 people, 6.45%
Sleep Disorder: 8 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Cholelithiasis?

- Check whether Cholelithiasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Cholelithiasis treatments and more:

Cholelithiasis (50,126 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Cholelithiasis:

Browse all the drugs that are associated with Cholelithiasis:

Cholelithiasis (2,725 drugs)

Common conditions associated with Cholelithiasis:

Hypertension: 3,488 reports
High blood pressure: 3,474 reports
Contraception: 3,430 reports
Birth control: 3,428 reports
Rheumatoid arthritis aggravated: 3,032 reports
Ms: 2,374 reports
Pain: 2,147 reports
Alternative medicine - pain relief: 2,133 reports
Depression: 1,723 reports
Antidepressant therapy: 1,718 reports

Browse all the conditions that are associated with Cholelithiasis:

Cholelithiasis (2,075 conditions)

Drugs similar to Codeine and Cholelithiasis :

Related publications that referenced our studies

Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .
Adak, I., & Coskun, M. , "Symptomatic cholelithiasis associated with combined use of methylphenidate and fluoxetine in an otherwise healthy adolescent girl", Psychiatry and Clinical Psychopharmacology, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.