Codeine and Elevated temperature - a phase IV clinical study of FDA data

Summary:

Elevated temperature is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Elevated temperature when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Elevated temperature?

Elevated temperature (high temperature) is found to be associated with 4,685 drugs and 6,211 conditions by eHealthMe. Check the latest studies of Elevated temperature.

On Oct, 09, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 2,584 people (6.19%) have Elevated temperature.

Could Codeine cause Elevated temperature?

Among these 2,584 people:

How long have people been on Codeine when they have Elevated temperature? *

What is the gender of people who have Elevated temperature when taking Codeine? *

female: 84.18 %
male: 15.82 %

What is the age of people who have Elevated temperature when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Elevated temperature? *

Fatigue (feeling of tiredness): 1,483 people, 57.39%
Rashes (redness): 1,243 people, 48.10%
High Blood Pressure: 1,132 people, 43.81%
Drug Ineffective: 1,128 people, 43.65%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1,115 people, 43.15%
Headache (pain in head): 1,073 people, 41.52%
Drug Intolerance (drug sensitivity): 1,052 people, 40.71%
Joint Pain: 1,047 people, 40.52%
Dyspnea (difficult or laboured breathing): 1,037 people, 40.13%
Joint Swelling: 1,016 people, 39.32%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1,275 people, 49.34%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 347 people, 13.43%
Herpes Zoster: 339 people, 13.12%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 282 people, 10.91%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 201 people, 7.78%
Psoriasis (immune-mediated disease that affects the skin): 195 people, 7.55%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 175 people, 6.77%
Indigestion: 169 people, 6.54%
Stress And Anxiety: 168 people, 6.50%
Depression: 135 people, 5.22%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Elevated temperature?

- Check whether Elevated temperature is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Elevated temperature:

Browse all the drugs that are associated with Elevated temperature:

Elevated temperature (4,685 drugs)

Common conditions associated with Elevated temperature:

Arthritis - rheumatoid: 27,612 reports
Multiple sclerosis aggravated: 20,065 reports
Hypertension aggravated: 16,478 reports
High blood pressure: 16,380 reports
Crohn's disease: 14,102 reports
Plasma cell dyscrasia: 12,143 reports
Pain exacerbated: 12,055 reports
Hypnosis and pain: 11,762 reports
Asthma: 9,798 reports
Exercise-induced asthma: 9,742 reports

Browse all the conditions that are associated with Elevated temperature:

Elevated temperature (6,211 conditions)

Drugs similar to Codeine and Elevated temperature :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.