Codeine and Fibrositis - a phase IV clinical study of FDA data

Summary:

Fibrositis is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 40-49 old, also take Xeljanz, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Fibrositis when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Fibrositis?

Fibrositis (a chronic pain disorder. the pain can be widespread throughout the body) is found to be associated with 2,282 drugs and 1,884 conditions by eHealthMe. Check the latest studies of Fibrositis.

On Oct, 28, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 1,258 people (3.02%) have Fibrositis.

Among these 1,258 people:

What is the gender of people who have Fibrositis when taking Codeine? *

female: 98.96 %
male: 1.04 %

What is the age of people who have Fibrositis when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Fibrositis? *

Joint Pain: 986 people, 78.38%
Fatigue (feeling of tiredness): 979 people, 77.82%
High Blood Cholesterol: 946 people, 75.20%
Joint Swelling: 919 people, 73.05%
Diarrhea: 905 people, 71.94%
Drug Ineffective: 891 people, 70.83%
Drug Intolerance (drug sensitivity): 842 people, 66.93%
Rashes (redness): 820 people, 65.18%
Synovitis (inflammation of the synovial membrane): 790 people, 62.80%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 779 people, 61.92%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1,109 people, 88.16%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 438 people, 34.82%
Psoriasis (immune-mediated disease that affects the skin): 265 people, 21.07%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 252 people, 20.03%
Stress And Anxiety: 195 people, 15.50%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 186 people, 14.79%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 182 people, 14.47%
Urticaria (rash of round, red welts on the skin that itch intensely): 153 people, 12.16%
Inflammation: 108 people, 8.59%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 101 people, 8.03%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Fibrositis?

- Check whether Fibrositis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Fibrositis treatments and more:

Fibrositis (92,967 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Fibrositis:

Browse all the drugs that are associated with Fibrositis:

Fibrositis (2,282 drugs)

Common conditions associated with Fibrositis:

Rheumatoid arthritis: 7,812 reports
Pain exacerbated: 2,523 reports
Pain relief: 2,516 reports
Psoriatic arthropathy aggravated: 2,394 reports
Fibromyalgia: 2,148 reports
Fibrositis: 1,973 reports
Depression: 1,700 reports
Antidepressant therapy: 1,698 reports
Fibromyositis: 1,513 reports
Osteoporosis: 1,411 reports

Browse all the conditions that are associated with Fibrositis:

Fibrositis (1,884 conditions)

Drugs similar to Codeine and Fibrositis :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.