Codeine and Flushing - a phase IV clinical study of FDA data

Summary:

Flushing is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, also take Zopiclone, and have Depression.

The phase IV clinical study analyzes which people have Flushing when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Flushing?

Flushing (the warm, red condition of human skin) is found to be associated with 2,046 drugs and 2,899 conditions by eHealthMe. Check the latest studies of Flushing.

On Jan, 14, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 199 people (0.48%) have Flushing.

Among these 199 people:

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Flushing?

- Check whether Flushing is associated with a drug or a condition (FREE)
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Flushing treatments and more:

Flushing (117,675 reports)

How severe was Flushing and when was it recovered:

Flushing in Codeine

Expand to all the drugs that have ingredients of codeine sulfate:

Flushing and drugs with ingredients of codeine sulfate (199 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Flushing:

Browse all the drugs that are associated with Flushing:

Flushing (2,046 drugs)

Common conditions associated with Flushing:

Multiple sclerosis aggravated: 22,392 reports
Blood cholesterol increased: 11,125 reports
Lipoprotein test: 11,039 reports
Reduce cholesterol: 10,836 reports
Lipid profile: 10,700 reports
Lower cholesterol: 10,648 reports
Familial primary pulmonary hypertension: 6,234 reports
High density lipoprotein decreased: 4,574 reports
Hypertension: 3,292 reports
Blood pressure - high: 3,262 reports

Browse all the conditions that are associated with Flushing:

Flushing (2,899 conditions)

Drugs similar to Codeine and Flushing :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.