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Codeine and Hyperbilirubinaemia aggravated - a phase IV clinical study of FDA data

Summary:

Hyperbilirubinaemia aggravated is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Acute myeloid leukaemia.

The phase IV clinical study analyzes which people have Hyperbilirubinaemia aggravated when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Hyperbilirubinaemia aggravated?

Hyperbilirubinaemia aggravated (excess of bilirubin in the blood) is found to be associated with 811 drugs and 377 conditions by eHealthMe. Check the latest studies of Hyperbilirubinaemia aggravated.

On Jul, 11, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 13 people (0.03%) have Hyperbilirubinaemia aggravated.

Could Codeine cause Hyperbilirubinaemia aggravated?

Among these 13 people:

How long have people been on Codeine when they have Hyperbilirubinaemia aggravated? *

  • < 1 month: 80 %
  • 1 - 6 months: 20 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyperbilirubinaemia aggravated when taking Codeine? *

  • female: 30.77 %
  • male: 69.23 %

What is the age of people who have Hyperbilirubinaemia aggravated when taking Codeine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.69 %
  • 30-39: 7.69 %
  • 40-49: 0.0 %
  • 50-59: 23.08 %
  • 60+: 61.54 %

What are other drugs people take besides Codeine? *

  1. Pantoprazole: 5 people, 38.46%
  2. Ondansetron: 5 people, 38.46%
  3. Paracetamol: 4 people, 30.77%
  4. Acyclovir: 4 people, 30.77%
  5. Aldactone: 4 people, 30.77%
  6. Allopurinol: 4 people, 30.77%
  7. Vancomycin: 4 people, 30.77%
  8. Piperacillin And Tazobactam: 3 people, 23.08%
  9. Oramorph Sr: 3 people, 23.08%
  10. Mylotarg: 3 people, 23.08%

What are other side effects people have besides Hyperbilirubinaemia aggravated? *

  1. Thrombocytopenia (decrease of platelets in blood): 4 people, 30.77%
  2. Fever: 3 people, 23.08%
  3. Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 23.08%
  4. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 23.08%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 23.08%
  6. Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 2 people, 15.38%
  7. Cholangitis (infection of the bile duct): 2 people, 15.38%
  8. Mucosal Inflammation (infection of mucous membrane): 2 people, 15.38%
  9. Oral Pain: 2 people, 15.38%
  10. Ascites (accumulation of fluid in the abdominal cavity): 2 people, 15.38%

What are the existing conditions these people have? *

  1. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 53.85%
  2. Nausea (feeling of having an urge to vomit): 5 people, 38.46%
  3. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 23.08%
  4. Diarrhea: 3 people, 23.08%
  5. Enterococcal Infection: 3 people, 23.08%
  6. Thrombocytopenia (decrease of platelets in blood): 2 people, 15.38%
  7. Stress And Anxiety: 2 people, 15.38%
  8. Acute Pulmonary Oedema (sudden deposit of fluid in the lung)): 2 people, 15.38%
  9. Constipation: 2 people, 15.38%
  10. Dyspnea (difficult or laboured breathing): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Hyperbilirubinaemia aggravated?

- Check whether Hyperbilirubinaemia aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Hyperbilirubinaemia aggravated treatments and more:

How severe was Hyperbilirubinaemia aggravated and when was it recovered:

Expand to all the drugs that have ingredients of codeine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperbilirubinaemia aggravated:

Browse all the conditions that are associated with Hyperbilirubinaemia aggravated:

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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