Codeine and Hypogammaglobulinaemia - a phase IV clinical study of FDA data

Summary:

Hypogammaglobulinaemia is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Paracetamol, and have Epilepsy.

The phase IV clinical study analyzes which people have Hypogammaglobulinaemia when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Hypogammaglobulinaemia?

Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection) is found to be associated with 551 drugs and 502 conditions by eHealthMe. Check the latest studies of Hypogammaglobulinaemia.

On Jul, 16, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 13 people (0.03%) have Hypogammaglobulinaemia.

Could Codeine cause Hypogammaglobulinaemia?

Among these 13 people:

How long have people been on Codeine when they have Hypogammaglobulinaemia? *

What is the gender of people who have Hypogammaglobulinaemia when taking Codeine? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Hypogammaglobulinaemia when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Hypogammaglobulinaemia? *

Joint Pain: 2 people, 15.38%
Pulmonary Sepsis (pus in lungs): 1 person, 7.69%
Gastroenteritis (inflammation of stomach and intestine): 1 person, 7.69%
Blood Immunoglobulin G Decreased: 1 person, 7.69%
Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 1 person, 7.69%
Chickenpox (infection with varicella zoster virus): 1 person, 7.69%
Cytomegalovirus Infection: 1 person, 7.69%
Dyspnea (difficult or laboured breathing): 1 person, 7.69%
Encephalitis Autoimmune (autoimmune origin disturbances of consciousness and pyramidal signs, inflammation of the brain): 1 person, 7.69%
Heart Rate Increased: 1 person, 7.69%

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 46.15%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 15.38%
Cough: 2 people, 15.38%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.69%
Insomnia (sleeplessness): 1 person, 7.69%
High Blood Pressure: 1 person, 7.69%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 7.69%
Gastritis (inflammation of stomach): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Hypogammaglobulinaemia?

- Check whether Hypogammaglobulinaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,342 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypogammaglobulinaemia:

Hypogammaglobulinaemia (551 drugs)

Browse all the conditions that are associated with Hypogammaglobulinaemia:

Hypogammaglobulinaemia (502 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.