Codeine and Ileitis - a phase IV clinical study of FDA data

Summary:

Ileitis is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Ileitis when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Ileitis?

Ileitis (inflammation of the ileum) is found to be associated with 2,253 drugs and 2,049 conditions by eHealthMe. Check the latest studies of Ileitis.



On Aug, 26, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 525 people (1.26%) have Ileitis.

Could Codeine cause Ileitis?

Among these 525 people:

How long have people been on Codeine when they have Ileitis? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Ileitis when taking Codeine? *

  • female: 68.51 %
  • male: 31.49 %

What is the age of people who have Ileitis when taking Codeine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.28 %
  • 20-29: 3.06 %
  • 30-39: 13.78 %
  • 40-49: 25.51 %
  • 50-59: 29.34 %
  • 60+: 27.04 %

What are other drugs people take besides Codeine? *

  1. Humira: 211 people, 40.19%
  2. Prednisone: 184 people, 35.05%
  3. Remicade: 172 people, 32.76%
  4. Stelara: 154 people, 29.33%
  5. Acetaminophen: 145 people, 27.62%
  6. Methotrexate: 141 people, 26.86%
  7. Folic Acid: 140 people, 26.67%
  8. Cimzia: 131 people, 24.95%
  9. Sulfasalazine: 130 people, 24.76%
  10. Simponi: 127 people, 24.19%

What are other side effects people have besides Ileitis? *

  1. Diarrhea: 178 people, 33.90%
  2. Drug Ineffective: 159 people, 30.29%
  3. Fatigue (feeling of tiredness): 141 people, 26.86%
  4. Nausea (feeling of having an urge to vomit): 136 people, 25.90%
  5. Joint Pain: 136 people, 25.90%
  6. High Blood Pressure: 133 people, 25.33%
  7. Drug Hypersensitivity: 128 people, 24.38%
  8. General Physical Health Deterioration (weak health status): 125 people, 23.81%
  9. Malaise (a feeling of general discomfort or uneasiness): 124 people, 23.62%
  10. Rashes (redness): 122 people, 23.24%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 134 people, 25.52%
  2. Psoriasis (immune-mediated disease that affects the skin): 82 people, 15.62%
  3. Ankylosing Spondylitis (type of arthritis affecting the spine): 71 people, 13.52%
  4. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 63 people, 12.00%
  5. Joint Pain: 56 people, 10.67%
  6. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 29 people, 5.52%
  7. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 23 people, 4.38%
  8. Sinusitis (inflammation of sinus): 19 people, 3.62%
  9. Diarrhea: 16 people, 3.05%
  10. Stress And Anxiety: 14 people, 2.67%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Ileitis?

- Check whether Ileitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Ileitis treatments and more:

How severe was Ileitis and when was it recovered:

Expand to all the drugs that have ingredients of codeine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ileitis:

Browse all the drugs that are associated with Ileitis:

Common conditions associated with Ileitis:

Browse all the conditions that are associated with Ileitis:

Drugs similar to Codeine and Ileitis :


How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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