1. Home
  2. Analysis
  3. Codeine
  4. Intestinal-ulcer

Codeine and Intestinal ulcer - a phase IV clinical study of FDA data

Summary:

Intestinal ulcer is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, also take Humira, and have Crohn's disease.

The phase IV clinical study analyzes which people have Intestinal ulcer when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Intestinal ulcer?

Intestinal ulcer is found to be associated with 267 drugs and 350 conditions by eHealthMe. Check the latest studies of Intestinal ulcer.

On Feb, 03, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 11 people (0.03%) have Intestinal ulcer.

Could Codeine cause Intestinal ulcer?

Among these 11 people:

What is the gender of people who have Intestinal ulcer when taking Codeine? *

  • female: 75 %
  • male: 25 %

What is the age of people who have Intestinal ulcer when taking Codeine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 9.09 %
  • 30-39: 9.09 %
  • 40-49: 0.0 %
  • 50-59: 9.09 %
  • 60+: 72.73 %

What are other drugs people take besides Codeine? *

  1. Humira: 6 people, 54.55%
  2. Wellbutrin: 5 people, 45.45%
  3. Norvasc: 5 people, 45.45%
  4. Aspirin: 5 people, 45.45%
  5. Clonidine: 5 people, 45.45%
  6. Cymbalta: 5 people, 45.45%
  7. Lomotil: 5 people, 45.45%
  8. Lopressor: 5 people, 45.45%
  9. Micardis: 5 people, 45.45%
  10. Nitrofurantoin: 5 people, 45.45%

What are other side effects people have besides Intestinal ulcer? *

  1. Weight Decreased: 5 people, 45.45%
  2. Pelvic Pain: 5 people, 45.45%
  3. Blood Magnesium Decreased: 5 people, 45.45%
  4. Blood Pressure Diastolic Decreased: 5 people, 45.45%
  5. Body Temperature Decreased: 5 people, 45.45%
  6. Bowel Movement Irregularity: 5 people, 45.45%
  7. Dizziness: 5 people, 45.45%
  8. Fatigue (feeling of tiredness): 5 people, 45.45%
  9. Heart Rate Decreased: 5 people, 45.45%
  10. Hypotension (abnormally low blood pressure): 5 people, 45.45%

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 54.55%
  2. Hepatic Neoplasm (liver tumour): 5 people, 45.45%
  3. Gastrointestinal Neoplasm (cancer tumour of digestive tract): 5 people, 45.45%
  4. Carcinoid Syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction): 5 people, 45.45%
  5. Neuroendocrine Carcinoma Metastatic (cancer tumour that arise from cells of the endocrine (hormonal) and nervous systems and spreads to other part): 4 people, 36.36%
  6. Diarrhea: 4 people, 36.36%
  7. Neuroendocrine Tumor: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Intestinal ulcer?

- Check whether Intestinal ulcer is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Intestinal ulcer treatments and more:

How severe was Intestinal ulcer and when was it recovered:

Expand to all the drugs that have ingredients of codeine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intestinal ulcer:

Browse all the conditions that are associated with Intestinal ulcer:

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.