Codeine and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 40-49 old, have been taking the drug for 1 - 2 years also take Prednisone, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint stiffness when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,307 drugs and 1,336 conditions by eHealthMe. Check the latest studies of Joint stiffness.

On Feb, 08, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 220 people (0.53%) have Joint stiffness.

Among these 220 people:

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,342 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

How severe was Joint stiffness and when was it recovered:

Joint stiffness in Codeine

Expand to all the drugs that have ingredients of codeine sulfate:

Joint stiffness and drugs with ingredients of codeine sulfate (220 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,307 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,336 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.