Codeine and Left ventricular dysfunction - a phase IV clinical study of FDA data

Summary:

Left ventricular dysfunction is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Ondansetron, and have Cough.

The phase IV clinical study analyzes which people have Left ventricular dysfunction when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Left ventricular dysfunction?

Left ventricular dysfunction is found to be associated with 956 drugs and 782 conditions by eHealthMe. Check the latest studies of Left ventricular dysfunction.

On Jul, 19, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 73 people (0.18%) have Left ventricular dysfunction.

Could Codeine cause Left ventricular dysfunction?

Among these 73 people:

How long have people been on Codeine when they have Left ventricular dysfunction? *

What is the gender of people who have Left ventricular dysfunction when taking Codeine? *

female: 90.16 %
male: 9.84 %

What is the age of people who have Left ventricular dysfunction when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Left ventricular dysfunction? *

Diarrhea: 50 people, 68.49%
Fatigue (feeling of tiredness): 49 people, 67.12%
Nausea (feeling of having an urge to vomit): 48 people, 65.75%
Rashes (redness): 47 people, 64.38%
Neuropathy Peripheral (surface nerve damage): 47 people, 64.38%
Abdominal Pain: 47 people, 64.38%
Headache (pain in head): 47 people, 64.38%
Depressed Mood: 46 people, 63.01%
Neuralgia (pain in one or more nerves): 46 people, 63.01%
Mucosal Inflammation (infection of mucous membrane): 46 people, 63.01%

What are the existing conditions these people have? *

Constipation: 48 people, 65.75%
Cough: 48 people, 65.75%
Wheezing (a high-pitched whistling sound made while you breath): 46 people, 63.01%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 46 people, 63.01%
Muscle Spasms (muscle contraction): 46 people, 63.01%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 46 people, 63.01%
Headache (pain in head): 46 people, 63.01%
Urinary Tract Infection: 46 people, 63.01%
Oropharyngeal Pain: 46 people, 63.01%
Diarrhea: 46 people, 63.01%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Left ventricular dysfunction?

- Check whether Left ventricular dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Left ventricular dysfunction treatments and more:

Left ventricular dysfunction (8,945 reports)

How severe was Left ventricular dysfunction and when was it recovered:

Left ventricular dysfunction in Codeine

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (956 drugs)

Browse all the conditions that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (782 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.