Codeine and Lightheadedness - a phase IV clinical study of FDA data

Summary:

Lightheadedness is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Lightheadedness when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Lightheadedness?

Lightheadedness (a common and often unpleasant sensation of dizziness and/or feeling that one may be about to faint) is found to be associated with 3,977 drugs and 5,752 conditions by eHealthMe. Check the latest studies of Lightheadedness.

On Sep, 25, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 2,513 people (6.02%) have Lightheadedness.

Among these 2,513 people:

How long have people been on Codeine when they have Lightheadedness? *

What is the gender of people who have Lightheadedness when taking Codeine? *

female: 83.39 %
male: 16.61 %

What is the age of people who have Lightheadedness when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Lightheadedness? *

Fatigue (feeling of tiredness): 1,513 people, 60.21%
Diarrhea: 1,330 people, 52.92%
Nausea (feeling of having an urge to vomit): 1,259 people, 50.10%
Headache (pain in head): 1,199 people, 47.71%
Joint Pain: 1,191 people, 47.39%
Weakness: 1,122 people, 44.65%
Nausea And Vomiting: 1,015 people, 40.39%
Dyspnea (difficult or laboured breathing): 968 people, 38.52%
Malaise (a feeling of general discomfort or uneasiness): 949 people, 37.76%
Drug Ineffective: 861 people, 34.26%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 899 people, 35.77%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 397 people, 15.80%
Depression: 327 people, 13.01%
Stress And Anxiety: 277 people, 11.02%
Psoriasis (immune-mediated disease that affects the skin): 269 people, 10.70%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 229 people, 9.11%
Indigestion: 208 people, 8.28%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 194 people, 7.72%
Diarrhea: 165 people, 6.57%
Urinary Tract Infection: 163 people, 6.49%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Lightheadedness?

- Check whether Lightheadedness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Lightheadedness treatments and more:

Lightheadedness (613,935 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Lightheadedness:

Browse all the drugs that are associated with Lightheadedness:

Lightheadedness (3,977 drugs)

Common conditions associated with Lightheadedness:

Hypertension: 33,072 reports
Blood pressure increased: 32,916 reports
High blood pressure: 32,915 reports
Ms: 29,675 reports
Ra: 25,674 reports
Rheumatoid arthritis: 25,672 reports
Depression: 22,809 reports
Antidepressant therapy: 22,796 reports
Pain exacerbated: 19,431 reports
Pain: 19,430 reports

Browse all the conditions that are associated with Lightheadedness:

Lightheadedness (5,752 conditions)

Drugs similar to Codeine and Lightheadedness :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.