Codeine and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Sandostatin, and have Carcinoid tumor of the gastrointestinal tract.

The phase IV clinical study analyzes which people have Major depression when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 805 drugs and 1,473 conditions by eHealthMe. Check the latest studies of Major depression.

On Apr, 06, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 33 people (0.08%) have Major depression.

Among these 33 people:

How long have people been on Codeine when they have Major depression? *

What is the gender of people who have Major depression when taking Codeine? *

female: 65.62 %
male: 34.38 %

What is the age of people who have Major depression when taking Codeine? *

What are other drugs people take besides Codeine? *

Sandostatin: 8 people, 24.24%
Paxil: 7 people, 21.21%
Acetaminophen: 6 people, 18.18%
Vicodin: 6 people, 18.18%
Hydrocodone Bitartrate And Acetaminophen: 6 people, 18.18%
Oxycontin: 6 people, 18.18%
Xanax: 5 people, 15.15%
Dexilant: 4 people, 12.12%
Citalopram Hydrobromide: 3 people, 9.09%
Dilaudid: 3 people, 9.09%

What are other side effects people have besides Major depression? *

Insomnia (sleeplessness): 12 people, 36.36%
Stress And Anxiety: 12 people, 36.36%
Fatigue (feeling of tiredness): 12 people, 36.36%
Head Injury: 11 people, 33.33%
Dizziness: 10 people, 30.30%
Suicide Attempt: 10 people, 30.30%
High Blood Pressure: 10 people, 30.30%
Drug Dependence: 10 people, 30.30%
Diarrhea: 9 people, 27.27%
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 8 people, 24.24%

What are the existing conditions these people have? *

Carcinoid Tumor Of The Gastrointestinal Tract: 8 people, 24.24%
Depression: 4 people, 12.12%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 12.12%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.12%
Stress And Anxiety: 3 people, 9.09%
Migraine (headache): 2 people, 6.06%
Allergic Rhinitis: 2 people, 6.06%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 3.03%
Joint Pain: 1 person, 3.03%
Insomnia (sleeplessness): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,342 reports)

Major depression treatments and more:

Major depression (44,974 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (805 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,473 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.