Codeine and Migraines - a phase IV clinical study of FDA data

Summary:

Migraines is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Migraines when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Migraines?

Migraines is found to be associated with 2,176 drugs and 2,303 conditions by eHealthMe. Check the latest studies of Migraines.

On Oct, 11, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 713 people (1.71%) have Migraines.

Among these 713 people:

How long have people been on Codeine when they have Migraines? *

What is the gender of people who have Migraines when taking Codeine? *

female: 92.94 %
male: 7.06 %

What is the age of people who have Migraines when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Migraines? *

Fatigue (feeling of tiredness): 413 people, 57.92%
Diarrhea: 371 people, 52.03%
Dizziness: 366 people, 51.33%
Nausea (feeling of having an urge to vomit): 324 people, 45.44%
Stress And Anxiety: 324 people, 45.44%
Headache (pain in head): 304 people, 42.64%
Malaise (a feeling of general discomfort or uneasiness): 290 people, 40.67%
Memory Loss: 283 people, 39.69%
Rashes (redness): 282 people, 39.55%
Weight Decreased: 277 people, 38.85%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 260 people, 36.47%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 208 people, 29.17%
Depression: 155 people, 21.74%
Stress And Anxiety: 138 people, 19.35%
Psoriasis (immune-mediated disease that affects the skin): 97 people, 13.60%
Urticaria (rash of round, red welts on the skin that itch intensely): 92 people, 12.90%
Asthma: 91 people, 12.76%
Itching: 90 people, 12.62%
Abdominal Pain: 89 people, 12.48%
Nausea And Vomiting: 89 people, 12.48%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Migraines?

- Check whether Migraines is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Migraines treatments and more:

Migraines (234,030 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Migraines:

Browse all the drugs that are associated with Migraines:

Migraines (2,176 drugs)

Common conditions associated with Migraines:

Ms hug: 8,583 reports
Multiple sclerosis: 8,559 reports
Migraines: 8,507 reports
Arthritis - rheumatoid: 6,236 reports
Ra: 6,216 reports
Antidepressant therapy: 3,865 reports
Contraception: 3,856 reports
Depression: 3,838 reports
Family planning and contraception: 3,785 reports
Pain: 3,766 reports

Browse all the conditions that are associated with Migraines:

Migraines (2,303 conditions)

Drugs similar to Codeine and Migraines :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.