Codeine and Nightmare - a phase IV clinical study of FDA data

Summary:

Nightmare is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Tylenol, and have Migraine.

The phase IV clinical study analyzes which people have Nightmare when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Nightmare?

Nightmare (unpleasant dream) is found to be associated with 1,619 drugs and 1,886 conditions by eHealthMe. Check the latest studies of Nightmare.

On Oct, 30, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 576 people (1.38%) have Nightmare.

Among these 576 people:

How long have people been on Codeine when they have Nightmare? *

What is the gender of people who have Nightmare when taking Codeine? *

female: 48.28 %
male: 51.72 %

What is the age of people who have Nightmare when taking Codeine? *

What are other drugs people take besides Codeine? *

Tylenol: 343 people, 59.55%
Demerol: 297 people, 51.56%
Toradol: 293 people, 50.87%
Maxalt: 289 people, 50.17%
Celebrex: 288 people, 50.00%
Diclofenac: 268 people, 46.53%
Topamax: 266 people, 46.18%
Gabapentin: 265 people, 46.01%
Venlafaxine Hydrochloride: 247 people, 42.88%
Ibuprofen: 237 people, 41.15%

What are other side effects people have besides Nightmare? *

Hyperhidrosis (abnormally increased sweating): 494 people, 85.76%
Nausea (feeling of having an urge to vomit): 398 people, 69.10%
Drug Ineffective: 366 people, 63.54%
Sedation: 361 people, 62.67%
Kidney Stones: 304 people, 52.78%
Stress And Anxiety: 213 people, 36.98%
Head Injury: 182 people, 31.60%
Dizziness: 180 people, 31.25%
Diarrhea: 178 people, 30.90%
Headache (pain in head): 172 people, 29.86%

What are the existing conditions these people have? *

Migraine (headache): 357 people, 61.98%
Depression: 164 people, 28.47%
Sedation: 106 people, 18.40%
Psychotic Disorder: 105 people, 18.23%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 104 people, 18.06%
Muscle Spasms (muscle contraction): 94 people, 16.32%
Neck Pain: 92 people, 15.97%
Post-Traumatic Stress Disorder: 92 people, 15.97%
Indigestion: 92 people, 15.97%
Neuralgia (pain in one or more nerves): 76 people, 13.19%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Nightmare?

- Check whether Nightmare is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Nightmare treatments and more:

Nightmare (42,075 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Nightmare:

Browse all the drugs that are associated with Nightmare:

Nightmare (1,619 drugs)

Common conditions associated with Nightmare:

Depression: 4,611 reports
Antidepressant therapy: 4,594 reports
Cessation of smoking: 2,948 reports
Pain: 2,558 reports
Alternative medicine - pain relief: 2,547 reports
Inability to sleep: 1,932 reports
Acupuncture and pain: 1,856 reports
Anxiety aggravated: 1,831 reports
Stress: 1,829 reports
Asthma aggravated: 1,225 reports

Browse all the conditions that are associated with Nightmare:

Nightmare (1,886 conditions)

Drugs similar to Codeine and Nightmare :

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.