Codeine and Nocturia - a phase IV clinical study of FDA data

Summary:

Nocturia is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are male, 50-59 old, also take Vitamin D3, and have Secondary progressive multiple sclerosis.

The phase IV clinical study analyzes which people have Nocturia when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Nocturia?

Nocturia (the need to get up in the night to urinate) is found to be associated with 1,744 drugs and 1,215 conditions by eHealthMe. Check the latest studies of Nocturia.

On Nov, 22, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 114 people (0.27%) have Nocturia.

Among these 114 people:

What is the gender of people who have Nocturia when taking Codeine? *

female: 19.59 %
male: 80.41 %

What is the age of people who have Nocturia when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Nocturia? *

Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 85 people, 74.56%
Stress And Anxiety: 81 people, 71.05%
Insomnia (sleeplessness): 79 people, 69.30%
Dizziness: 79 people, 69.30%
Fall: 78 people, 68.42%
Balance Disorder: 77 people, 67.54%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 74 people, 64.91%
Memory Loss: 74 people, 64.91%
Bradycardia (abnormally slow heart action): 73 people, 64.04%
Movement - Uncoordinated: 72 people, 63.16%

What are the existing conditions these people have? *

Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 70 people, 61.40%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 12 people, 10.53%
High Blood Pressure: 7 people, 6.14%
Diarrhea: 6 people, 5.26%
Muscle Strain (an injury to a muscle in which the muscle fibres tear): 5 people, 4.39%
Parkinson's Disease: 5 people, 4.39%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 3.51%
Abnormal Faeces (abnormal stool): 4 people, 3.51%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 3.51%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 4 people, 3.51%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Nocturia?

- Check whether Nocturia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Nocturia treatments and more:

Nocturia (17,711 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Nocturia:

Browse all the drugs that are associated with Nocturia:

Nocturia (1,744 drugs)

Common conditions associated with Nocturia:

Shaking palsy: 1,266 reports
Hypertension: 1,069 reports
Blood pressure - high: 1,059 reports
Prostate cancer: 735 reports
Cancer - prostate: 733 reports
Osteoporosis: 701 reports
Gerds: 619 reports
High blood cholesterol and triglycerides: 568 reports
Hypercholesterolaemia: 567 reports
Lipoprotein test: 500 reports

Browse all the conditions that are associated with Nocturia:

Nocturia (1,215 conditions)

Drugs similar to Codeine and Nocturia :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.