Codeine and Osteolysis - a phase IV clinical study of FDA data

Summary:

Osteolysis is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are male, 50-59 old, also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Osteolysis when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Osteolysis?

Osteolysis (dissolution of bone) is found to be associated with 688 drugs and 407 conditions by eHealthMe. Check the latest studies of Osteolysis.

On Apr, 13, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 20 people (0.05%) have Osteolysis.

Among these 20 people:

What is the gender of people who have Osteolysis when taking Codeine? *

female: 50 %
male: 50 %

What is the age of people who have Osteolysis when taking Codeine? *

What are other drugs people take besides Codeine? *

Zometa: 19 people, 95.00%
Hydrochlorothiazide: 18 people, 90.00%
Zestril: 13 people, 65.00%
Amoxicillin: 12 people, 60.00%
Bortezomib: 12 people, 60.00%
Vancomycin: 12 people, 60.00%
Acyclovir: 11 people, 55.00%
Gabapentin: 11 people, 55.00%
Fluconazole: 10 people, 50.00%
Chlorhexidine Gluconate: 9 people, 45.00%

What are other side effects people have besides Osteolysis? *

Osteonecrosis Of Jaw (death of bone of jaw): 19 people, 95.00%
Stress And Anxiety: 19 people, 95.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 19 people, 95.00%
Joint Pain: 18 people, 90.00%
Tricuspid Valve Incompetence (inefficient heart valve): 15 people, 75.00%
Chest Pain: 15 people, 75.00%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 15 people, 75.00%
Dry Eyes (lack of adequate tears): 14 people, 70.00%
Neuropathy Peripheral (surface nerve damage): 14 people, 70.00%
Depression: 14 people, 70.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 45.00%
Metastasis (spreadable cancer to other organ from origin): 5 people, 25.00%
High Blood Pressure: 5 people, 25.00%
Weight Decreased: 1 person, 5.00%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 1 person, 5.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.00%
Prostate Cancer: 1 person, 5.00%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 5.00%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Osteolysis?

- Check whether Osteolysis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,342 reports)

Osteolysis treatments and more:

Osteolysis (4,092 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteolysis:

Osteolysis (688 drugs)

Browse all the conditions that are associated with Osteolysis:

Osteolysis (407 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.