Codeine and Primary sequestrum - a phase IV clinical study of FDA data

Summary:

Primary sequestrum is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Primary sequestrum when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Primary sequestrum?

Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone) is found to be associated with 606 drugs and 324 conditions by eHealthMe. Check the latest studies of Primary sequestrum.

On Dec, 21, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 37 people (0.09%) have Primary sequestrum.

Among these 37 people:

What is the gender of people who have Primary sequestrum when taking Codeine? *

female: 81.08 %
male: 18.92 %

What is the age of people who have Primary sequestrum when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Primary sequestrum? *

Stress And Anxiety: 36 people, 97.30%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 35 people, 94.59%
Osteonecrosis Of Jaw (death of bone of jaw): 34 people, 91.89%
Deformity (disfigurement): 33 people, 89.19%
Osteomyelitis (infection of bone): 28 people, 75.68%
Depression: 27 people, 72.97%
Infection: 27 people, 72.97%
Neuropathy Peripheral (surface nerve damage): 25 people, 67.57%
Intervertebral Disc Protrusion (spinal disc protrusion): 25 people, 67.57%
Spinal Osteoarthritis (joint cartilage loss in spine): 24 people, 64.86%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 19 people, 51.35%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 12 people, 32.43%
Breast Cancer: 10 people, 27.03%
Stress And Anxiety: 8 people, 21.62%
Metastases To Bone (cancer spreads to bone): 8 people, 21.62%
Bone Pain: 7 people, 18.92%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 7 people, 18.92%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 18.92%
Breast Cancer Metastatic: 3 people, 8.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Primary sequestrum?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Primary sequestrum:

Primary sequestrum (606 drugs)

Browse all the conditions that are associated with Primary sequestrum:

Primary sequestrum (324 conditions)

Drugs similar to Codeine and Primary sequestrum :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.