Codeine and Pyrosis - a phase IV clinical study of FDA data

Summary:

Pyrosis is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Pyrosis when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Pyrosis?

Pyrosis (painful burning sensation in the chest caused by gastroesophageal reflux) is found to be associated with 3,596 drugs and 3,458 conditions by eHealthMe. Check the latest studies of Pyrosis.

On Nov, 22, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 421 people (1.01%) have Pyrosis.

Among these 421 people:

How long have people been on Codeine when they have Pyrosis? *

What is the gender of people who have Pyrosis when taking Codeine? *

female: 77.57 %
male: 22.43 %

What is the age of people who have Pyrosis when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Pyrosis? *

Nausea (feeling of having an urge to vomit): 211 people, 50.12%
Diarrhea: 173 people, 41.09%
Headache (pain in head): 172 people, 40.86%
Stress And Anxiety: 147 people, 34.92%
Dizziness: 146 people, 34.68%
Weight Decreased: 144 people, 34.20%
Hypoaesthesia (reduced sense of touch or sensation): 143 people, 33.97%
Fatigue (feeling of tiredness): 141 people, 33.49%
Nausea And Vomiting: 123 people, 29.22%
Indigestion: 123 people, 29.22%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 87 people, 20.67%
Depression: 63 people, 14.96%
Migraine (headache): 61 people, 14.49%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 51 people, 12.11%
High Blood Pressure: 50 people, 11.88%
Asthma: 40 people, 9.50%
Psoriasis (immune-mediated disease that affects the skin): 39 people, 9.26%
Stress And Anxiety: 30 people, 7.13%
Nausea (feeling of having an urge to vomit): 29 people, 6.89%
Diabetes: 28 people, 6.65%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Pyrosis?

- Check whether Pyrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Pyrosis treatments and more:

Pyrosis (445,732 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Pyrosis:

Browse all the drugs that are associated with Pyrosis:

Pyrosis (3,596 drugs)

Common conditions associated with Pyrosis:

Hypertension: 8,809 reports
Htn: 8,796 reports
Gastroesophageal reflux disease: 8,087 reports
Pyrosis: 7,618 reports
Osteoporosis: 6,424 reports
Thin bones: 6,141 reports
Reflux esophagitis: 5,786 reports
Pain: 5,547 reports
Pain relief: 5,525 reports
Gastrooesophageal reflux disease: 5,263 reports

Browse all the conditions that are associated with Pyrosis:

Pyrosis (3,458 conditions)

Drugs similar to Codeine and Pyrosis :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.