Codeine and Sleepiness - a phase IV clinical study of FDA data

Summary:

Sleepiness is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Acetaminophen, and have Depression.

The phase IV clinical study analyzes which people have Sleepiness when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Sleepiness?

Sleepiness (excess sleeping) is found to be associated with 4,102 drugs and 4,802 conditions by eHealthMe. Check the latest studies of Sleepiness.

On Aug, 01, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 1,326 people (3.18%) have Sleepiness.

Among these 1,326 people:

How long have people been on Codeine when they have Sleepiness? *

What is the gender of people who have Sleepiness when taking Codeine? *

female: 75.47 %
male: 24.53 %

What is the age of people who have Sleepiness when taking Codeine? *

What are other drugs people take besides Codeine? *

Acetaminophen: 333 people, 25.11%
Mirtazapine: 257 people, 19.38%
Pregabalin: 236 people, 17.80%
Aspirin: 234 people, 17.65%
Venlafaxine Hydrochloride: 223 people, 16.82%
Hydrochlorothiazide: 218 people, 16.44%
Celecoxib: 216 people, 16.29%
Buprenorphine: 216 people, 16.29%
Nitroglycerin: 211 people, 15.91%
Zoledronic Acid: 209 people, 15.76%

What are other side effects people have besides Sleepiness? *

Fatigue (feeling of tiredness): 598 people, 45.10%
Diarrhea: 500 people, 37.71%
Headache (pain in head): 477 people, 35.97%
Dizziness: 452 people, 34.09%
Nausea (feeling of having an urge to vomit): 452 people, 34.09%
Malaise (a feeling of general discomfort or uneasiness): 438 people, 33.03%
Joint Pain: 427 people, 32.20%
Nausea And Vomiting: 405 people, 30.54%
Weakness: 400 people, 30.17%
Itching: 387 people, 29.19%

What are the existing conditions these people have? *

Depression: 140 people, 10.56%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 118 people, 8.90%
Neck Pain: 72 people, 5.43%
Neuralgia (pain in one or more nerves): 70 people, 5.28%
Muscle Spasms (muscle contraction): 68 people, 5.13%
Psychotic Disorder: 67 people, 5.05%
Sedation: 66 people, 4.98%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 65 people, 4.90%
Indigestion: 64 people, 4.83%
Migraine (headache): 59 people, 4.45%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Sleepiness?

- Check whether Sleepiness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Sleepiness treatments and more:

Sleepiness (269,039 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sleepiness:

Browse all the drugs that are associated with Sleepiness:

Sleepiness (4,102 drugs)

Common conditions associated with Sleepiness:

Pain exacerbated: 12,747 reports
Hypnosis and pain: 12,587 reports
Depression: 11,548 reports
Antidepressant therapy: 11,506 reports
Multiple sclerosis aggravated: 9,554 reports
Hypertension: 9,266 reports
Hbp: 9,215 reports
Acupuncture and pain: 6,871 reports
Anxiety: 6,828 reports
Anxiety and stress: 6,819 reports

Browse all the conditions that are associated with Sleepiness:

Sleepiness (4,802 conditions)

Drugs similar to Codeine and Sleepiness :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.