Codeine and Sluggishness - a phase IV clinical study of FDA data

Summary:

Sluggishness is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Sertraline, and have Carcinoid tumor.

The phase IV clinical study analyzes which people have Sluggishness when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Sluggishness?

Sluggishness (lacking alertness) is found to be associated with 832 drugs and 744 conditions by eHealthMe. Check the latest studies of Sluggishness.

On Apr, 22, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 29 people (0.07%) have Sluggishness.

Among these 29 people:

How long have people been on Codeine when they have Sluggishness? *

What is the gender of people who have Sluggishness when taking Codeine? *

female: 51.85 %
male: 48.15 %

What is the age of people who have Sluggishness when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Sluggishness? *

Fatigue (feeling of tiredness): 19 people, 65.52%
Pain In Extremity: 18 people, 62.07%
Gait Disturbance: 15 people, 51.72%
Diarrhea: 13 people, 44.83%
Constipation: 13 people, 44.83%
Chest Pain: 12 people, 41.38%
Sleep Disorder: 12 people, 41.38%
Heart Rate Irregular: 10 people, 34.48%
Nausea (feeling of having an urge to vomit): 9 people, 31.03%
Weakness: 9 people, 31.03%

What are the existing conditions these people have? *

Carcinoid Tumor: 7 people, 24.14%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 5 people, 17.24%
Cough: 5 people, 17.24%
Essential Hypertension (primary hypertension): 3 people, 10.34%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 10.34%
Gastric Disorder (disease of stomach): 2 people, 6.90%
High Blood Pressure: 2 people, 6.90%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 6.90%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.90%
Sleep Disorder: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Sluggishness?

- Check whether Sluggishness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,342 reports)

Sluggishness treatments and more:

Sluggishness (11,737 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sluggishness:

Sluggishness (832 drugs)

Browse all the conditions that are associated with Sluggishness:

Sluggishness (744 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.