Codeine and Social avoidant behavior - a phase IV clinical study of FDA data

Summary:

Social avoidant behavior is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Oxycontin, and have Depression.

The phase IV clinical study analyzes which people have Social avoidant behavior when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Social avoidant behavior?

Social avoidant behavior is found to be associated with 494 drugs and 602 conditions by eHealthMe. Check the latest studies of Social avoidant behavior.

On Nov, 27, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 11 people (0.03%) have Social avoidant behavior.

Could Codeine cause Social avoidant behavior?

Among these 11 people:

How long have people been on Codeine when they have Social avoidant behavior? *

What is the gender of people who have Social avoidant behavior when taking Codeine? *

female: 44.44 %
male: 55.56 %

What is the age of people who have Social avoidant behavior when taking Codeine? *

What are other drugs people take besides Codeine? *

Oxycontin: 3 people, 27.27%
Ms Contin: 2 people, 18.18%
Zithromax: 2 people, 18.18%
Cipro: 2 people, 18.18%
Cymbalta: 2 people, 18.18%
Demerol: 2 people, 18.18%
Gravol: 2 people, 18.18%
Hydrocodone Bitartrate And Acetaminophen: 2 people, 18.18%
Keflex: 2 people, 18.18%
Marijuana: 2 people, 18.18%

What are other side effects people have besides Social avoidant behavior? *

Drug Dependence: 6 people, 54.55%
Hyperhidrosis (abnormally increased sweating): 4 people, 36.36%
Suicidal Ideation: 4 people, 36.36%
Abdominal Pain: 4 people, 36.36%
Weakness: 3 people, 27.27%
Depression: 3 people, 27.27%
Emotional Distress: 3 people, 27.27%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 3 people, 27.27%
Tooth Disorder (tooth disease): 2 people, 18.18%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 18.18%

What are the existing conditions these people have? *

Drug Dependence: 3 people, 27.27%
Depression: 3 people, 27.27%
Vagus Nerve Disorder: 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 2 people, 18.18%
Breakthrough Pain: 2 people, 18.18%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Social avoidant behavior?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Social avoidant behavior:

Social avoidant behavior (494 drugs)

Browse all the conditions that are associated with Social avoidant behavior:

Social avoidant behavior (602 conditions)

Drugs similar to Codeine and Social avoidant behavior :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.