Colofac and Sedation aggravated - a phase IV clinical study of FDA data

Summary:

Sedation aggravated is reported as a side effect among people who take Colofac (mebeverine hydrochloride), especially for people who are male, also take Nexium, and have Depression.

The phase IV clinical study analyzes which people have Sedation aggravated when taking Colofac. It is created by eHealthMe based on reports of 317 people who have side effects when taking Colofac from the FDA, and is updated regularly.

What is Colofac?

Colofac has active ingredients of mebeverine hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 375 Colofac users. Check the latest studies of Colofac.

What is Sedation aggravated?

Sedation aggravated is found to be associated with 1,153 drugs and 493 conditions by eHealthMe. Check the latest studies of Sedation aggravated.

On Jul, 17, 2026

317 people reported to have side effects when taking Colofac.
Among them, 13 people (4.1%) have Sedation aggravated.

Could Colofac cause Sedation aggravated?

Among these 13 people:

What is the gender of people who have Sedation aggravated when taking Colofac? *

female: 0.0 %
male: 100 %

What are other drugs people take besides Colofac? *

Nexium: 12 people, 92.31%
Ranitidine: 9 people, 69.23%
Doxazosin Mesylate: 8 people, 61.54%
Ranitidine Hydrochloride: 3 people, 23.08%
Anafranil: 3 people, 23.08%
Bisoprolol Fumarate: 2 people, 15.38%
Amitriptyline Hydrochloride: 1 person, 7.69%

What are other side effects people have besides Sedation aggravated? *

Fatigue (feeling of tiredness): 13 people, 100.00%
Drowsiness: 1 person, 7.69%

What are the existing conditions these people have? *

Depression: 12 people, 92.31%

* Approximation only. Some reports may have incomplete information.

Do you take Colofac and have Sedation aggravated?

- Check whether Sedation aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Colofac:

Colofac (375 reports)

Browse all side effects of Colofac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sedation aggravated:

Sedation aggravated (1,153 drugs)

Browse all the conditions that are associated with Sedation aggravated:

Sedation aggravated (493 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on mebeverine hydrochloride (the active ingredients of Colofac) and Colofac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.