Combigan and Bladder disorder - a phase IV clinical study of FDA data

Summary:

Bladder disorder is reported as a side effect among people who take Combigan (brimonidine tartrate; timolol maleate), especially for people who are male, 60+ old, also take Lumigan, and have Polycythaemia vera.

The phase IV clinical study analyzes which people have Bladder disorder when taking Combigan. It is created by eHealthMe based on reports of 7,653 people who have side effects when taking Combigan from the FDA, and is updated regularly.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

What is Bladder disorder?

Bladder disorder is found to be associated with 900 drugs and 896 conditions by eHealthMe. Check the latest studies of Bladder disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

7,653 people reported to have side effects when taking Combigan.
Among them, 15 people (0.2%) have Bladder disorder.

Among these 15 people:

What is the gender of people who have Bladder disorder when taking Combigan? *

female: 14.29 %
male: 85.71 %

What is the age of people who have Bladder disorder when taking Combigan? *

What are other drugs people take besides Combigan? *

Lumigan: 14 people, 93.33%
Jakafi: 8 people, 53.33%
Vitamin D3: 8 people, 53.33%
Clopidogrel: 8 people, 53.33%
Magnesium: 8 people, 53.33%
Calcium: 5 people, 33.33%
Voltaren: 5 people, 33.33%
Tylenol: 5 people, 33.33%
Nuplazid: 4 people, 26.67%
Carbidopa And Levodopa: 4 people, 26.67%

What are other side effects people have besides Bladder disorder? *

Diarrhea: 12 people, 80.00%
Platelet Count Increased: 8 people, 53.33%
Red Blood Cell Count Abnormal: 8 people, 53.33%
Weakness: 8 people, 53.33%
Intraocular Pressure Increased: 8 people, 53.33%
Fatigue (feeling of tiredness): 8 people, 53.33%
Muscle Injury: 8 people, 53.33%
Muscle Spasms (muscle contraction): 8 people, 53.33%
Oedema Peripheral (superficial swelling): 8 people, 53.33%
Pain In Extremity: 8 people, 53.33%

What are the existing conditions these people have? *

Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 8 people, 53.33%
Parkinson's Disease: 4 people, 26.67%
On And Off Phenomenon: 4 people, 26.67%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 13.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Combigan and have Bladder disorder?

- Check whether Bladder disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combigan:

Combigan (7,810 reports)

Bladder disorder treatments and more:

Bladder disorder (20,149 reports)

How severe was Bladder disorder and when was it recovered:

Bladder disorder in Combigan

Expand to all the drugs that have ingredients of brimonidine tartrate; timolol maleate:

Bladder disorder and drugs with ingredients of brimonidine tartrate; timolol maleate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combigan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bladder disorder:

Bladder disorder (900 drugs)

Browse all the conditions that are associated with Bladder disorder:

Bladder disorder (896 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate; timolol maleate (the active ingredients of Combigan) and Combigan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.