Combigan and Staphylococcal infection - a phase IV clinical study of FDA data

Summary:

Staphylococcal infection is reported as a side effect among people who take Combigan (brimonidine tartrate; timolol maleate), especially for people who are female, 60+ old, also take Synthroid, and have Asthma.

The phase IV clinical study analyzes which people have Staphylococcal infection when taking Combigan. It is created by eHealthMe based on reports of 7,653 people who have side effects when taking Combigan from the FDA, and is updated regularly.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

What is Staphylococcal infection?

Staphylococcal infection (an infection with staphylococcus bacteria) is found to be associated with 1,722 drugs and 1,898 conditions by eHealthMe. Check the latest studies of Staphylococcal infection.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

7,653 people reported to have side effects when taking Combigan.
Among them, 15 people (0.2%) have Staphylococcal infection.

Could Combigan cause Staphylococcal infection?

Among these 15 people:

What is the gender of people who have Staphylococcal infection when taking Combigan? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Staphylococcal infection when taking Combigan? *

What are other drugs people take besides Combigan? *

What are other side effects people have besides Staphylococcal infection? *

Pneumonia: 3 people, 20.00%
Weakness: 2 people, 13.33%
Cataract (clouding of the lens inside the eye): 2 people, 13.33%
Viral Infection: 2 people, 13.33%
Intervertebral Disc Protrusion (spinal disc protrusion): 2 people, 13.33%
Swallowing Difficulty: 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
Sinusitis (inflammation of sinus): 2 people, 13.33%
Osteomyelitis (infection of bone): 2 people, 13.33%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 13.33%

What are the existing conditions these people have? *

Asthma: 5 people, 33.33%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 20.00%
Vitamin D Decreased: 2 people, 13.33%
Migraine (headache): 2 people, 13.33%
Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 2 people, 13.33%
Bladder Disorder: 2 people, 13.33%
Blood Pressure Abnormal: 2 people, 13.33%
Delusion (a false belief or opinion): 2 people, 13.33%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Combigan and have Staphylococcal infection?

- Check whether Staphylococcal infection is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combigan:

Combigan (7,810 reports)

Staphylococcal infection treatments and more:

Staphylococcal infection (52,105 reports)

How severe was Staphylococcal infection and when was it recovered:

Staphylococcal infection in Combigan

Expand to all the drugs that have ingredients of brimonidine tartrate; timolol maleate:

Staphylococcal infection and drugs with ingredients of brimonidine tartrate; timolol maleate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combigan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Staphylococcal infection:

Staphylococcal infection (1,722 drugs)

Browse all the conditions that are associated with Staphylococcal infection:

Staphylococcal infection (1,898 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate; timolol maleate (the active ingredients of Combigan) and Combigan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.