Combivent and Sinus bradycardia - a phase IV clinical study of FDA data

Summary:

Sinus bradycardia is reported as a side effect among people who take Combivent (albuterol sulfate; ipratropium bromide), especially for people who are male, 50-59 old, have been taking the drug for 5 - 10 years also take Aspirin, and have Bone density abnormal.

The phase IV clinical study analyzes which people have Sinus bradycardia when taking Combivent. It is created by eHealthMe based on reports of 35,104 people who have side effects when taking Combivent from the FDA, and is updated regularly.

What is Combivent?

Combivent has active ingredients of albuterol sulfate; ipratropium bromide. It is often used in asthma. eHealthMe is studying from 35,341 Combivent users. Check the latest studies of Combivent.

What is Sinus bradycardia?

Sinus bradycardia (an unusually slow heartbeat due to heart disease) is found to be associated with 898 drugs and 1,055 conditions by eHealthMe. Check the latest studies of Sinus bradycardia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

35,104 people reported to have side effects when taking Combivent.
Among them, 40 people (0.11%) have Sinus bradycardia.

Could Combivent cause Sinus bradycardia?

Among these 40 people:

How long have people been on Combivent when they have Sinus bradycardia? *

What is the gender of people who have Sinus bradycardia when taking Combivent? *

female: 50 %
male: 50 %

What is the age of people who have Sinus bradycardia when taking Combivent? *

What are other drugs people take besides Combivent? *

What are other side effects people have besides Sinus bradycardia? *

Chest Pain: 18 people, 45.00%
Stress And Anxiety: 17 people, 42.50%
Injury: 17 people, 42.50%
Insomnia (sleeplessness): 16 people, 40.00%
Nausea (feeling of having an urge to vomit): 16 people, 40.00%
Oedema Peripheral (superficial swelling): 16 people, 40.00%
Pain: 16 people, 40.00%
Depression: 16 people, 40.00%
Acute Kidney Failure: 16 people, 40.00%
Fall: 15 people, 37.50%

What are the existing conditions these people have? *

Bone Density Abnormal: 10 people, 25.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 12.50%
High Blood Cholesterol: 4 people, 10.00%
Stable Angina (a constant chest pain): 3 people, 7.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.50%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 2 people, 5.00%
Cardiac Disorder: 2 people, 5.00%
Heart Disease: 2 people, 5.00%
High Blood Pressure: 2 people, 5.00%
Vertigo Positional: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Combivent and have Sinus bradycardia?

- Check whether Sinus bradycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combivent:

Combivent (35,341 reports)

Sinus bradycardia treatments and more:

Sinus bradycardia (12,848 reports)

How severe was Sinus bradycardia and when was it recovered:

Sinus bradycardia in Combivent

Expand to all the drugs that have ingredients of albuterol sulfate; ipratropium bromide:

Sinus bradycardia and drugs with ingredients of albuterol sulfate; ipratropium bromide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combivent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus bradycardia:

Sinus bradycardia (898 drugs)

Browse all the conditions that are associated with Sinus bradycardia:

Sinus bradycardia (1,055 conditions)

Related publications that referenced our studies

Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .
Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on albuterol sulfate; ipratropium bromide (the active ingredients of Combivent) and Combivent (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.