Combivir and Intervertebral disc protrusion - a phase IV clinical study of FDA data

Summary:

Intervertebral disc protrusion is reported as a side effect among people who take Combivir (lamivudine; zidovudine), especially for people who are male, 40-49 old, have been taking the drug for 5 - 10 years also take Kaletra, and have Drug exposure during pregnancy.

The phase IV clinical study analyzes which people have Intervertebral disc protrusion when taking Combivir. It is created by eHealthMe based on reports of 15,371 people who have side effects when taking Combivir from the FDA, and is updated regularly.

What is Combivir?

Combivir has active ingredients of lamivudine; zidovudine. It is often used in hiv infection. eHealthMe is studying from 15,450 Combivir users. Check the latest studies of Combivir.

What is Intervertebral disc protrusion?

Intervertebral disc protrusion (spinal disc protrusion) is found to be associated with 1,535 drugs and 1,305 conditions by eHealthMe. Check the latest studies of Intervertebral disc protrusion.

On Jun, 17, 2026

15,371 people reported to have side effects when taking Combivir.
Among them, 17 people (0.11%) have Intervertebral disc protrusion.

Could Combivir cause Intervertebral disc protrusion?

Among these 17 people:

How long have people been on Combivir when they have Intervertebral disc protrusion? *

What is the gender of people who have Intervertebral disc protrusion when taking Combivir? *

female: 35.29 %
male: 64.71 %

What is the age of people who have Intervertebral disc protrusion when taking Combivir? *

What are other drugs people take besides Combivir? *

What are other side effects people have besides Intervertebral disc protrusion? *

Stress And Anxiety: 11 people, 64.71%
Emotional Distress: 9 people, 52.94%
Pain: 9 people, 52.94%
Back Pain: 8 people, 47.06%
Depression: 8 people, 47.06%
Bone Density Decreased: 7 people, 41.18%
Osteoporosis (bones weak and more likely to break): 7 people, 41.18%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 7 people, 41.18%
Acute Kidney Failure: 7 people, 41.18%
Joint Pain: 5 people, 29.41%

What are the existing conditions these people have? *

Thyroid Diseases: 1 person, 5.88%
Stress And Anxiety: 1 person, 5.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
Oesophageal Disorder (disease of oesophagus): 1 person, 5.88%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.88%
Metastases To Bone (cancer spreads to bone): 1 person, 5.88%
Lipids Increased (excess lipid in body): 1 person, 5.88%
Insomnia (sleeplessness): 1 person, 5.88%
Herpes Virus Infection: 1 person, 5.88%
Drug Exposure During Pregnancy: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Combivir and have Intervertebral disc protrusion?

- Check whether Intervertebral disc protrusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combivir:

Combivir (15,450 reports)

Browse all side effects of Combivir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,535 drugs)

Browse all the conditions that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,305 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lamivudine; zidovudine (the active ingredients of Combivir) and Combivir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.