Combivir and Mitral valve incompetence - a phase IV clinical study of FDA data

Summary:

Mitral valve incompetence is reported as a side effect among people who take Combivir (lamivudine; zidovudine), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Lorazepam, and have High blood pressure.

The phase IV clinical study analyzes which people have Mitral valve incompetence when taking Combivir. It is created by eHealthMe based on reports of 15,371 people who have side effects when taking Combivir from the FDA, and is updated regularly.

What is Combivir?

Combivir has active ingredients of lamivudine; zidovudine. It is often used in hiv infection. eHealthMe is studying from 15,450 Combivir users. Check the latest studies of Combivir.

What is Mitral valve incompetence?

Mitral valve incompetence (inefficient heart valve) is found to be associated with 1,437 drugs and 1,279 conditions by eHealthMe. Check the latest studies of Mitral valve incompetence.

On Aug, 02, 2026

15,371 people reported to have side effects when taking Combivir.
Among them, 19 people (0.12%) have Mitral valve incompetence.

Could Combivir cause Mitral valve incompetence?

Among these 19 people:

How long have people been on Combivir when they have Mitral valve incompetence? *

What is the gender of people who have Mitral valve incompetence when taking Combivir? *

female: 73.68 %
male: 26.32 %

What is the age of people who have Mitral valve incompetence when taking Combivir? *

What are other drugs people take besides Combivir? *

What are other side effects people have besides Mitral valve incompetence? *

Cardiac Failure Congestive: 13 people, 68.42%
Dyspnea (difficult or laboured breathing): 11 people, 57.89%
Congestive Cardiomyopathy (weakening of heart muscle): 9 people, 47.37%
Dilatation Ventricular: 9 people, 47.37%
Dyspnea Exertional: 9 people, 47.37%
Pericardial Effusion (fluid around the heart): 9 people, 47.37%
Pulmonary Oedema (fluid accumulation in the lungs): 7 people, 36.84%
Mitral Valve Calcification (calcium deposit in mitral valve): 7 people, 36.84%
Weight Decreased: 7 people, 36.84%
Cardiac Disorder: 7 people, 36.84%

What are the existing conditions these people have? *

Viral Infection: 1 person, 5.26%
Uveitis (inflammation of the uvea): 1 person, 5.26%
Thyroid Cancer Metastatic (thyroid cancer spreads to other part): 1 person, 5.26%
Stress And Anxiety: 1 person, 5.26%
Pain: 1 person, 5.26%
Migraine (headache): 1 person, 5.26%
Insomnia (sleeplessness): 1 person, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.26%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 1 person, 5.26%
High Blood Pressure: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Combivir and have Mitral valve incompetence?

- Check whether Mitral valve incompetence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combivir:

Combivir (15,450 reports)

Browse all side effects of Combivir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve incompetence:

Mitral valve incompetence (1,437 drugs)

Browse all the conditions that are associated with Mitral valve incompetence:

Mitral valve incompetence (1,279 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lamivudine; zidovudine (the active ingredients of Combivir) and Combivir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.