Commit and Agitation - a phase IV clinical study of FDA data

Summary:

Agitation is reported as a side effect among people who take Commit (nicotine polacrilex), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Nicoderm Cq, and have Quit smoking.

The phase IV clinical study analyzes which people have Agitation when taking Commit. It is created by eHealthMe based on reports of 4,836 people who have side effects when taking Commit from the FDA, and is updated regularly.

What is Commit?

Commit has active ingredients of nicotine polacrilex. eHealthMe is studying from 4,842 Commit users. Check the latest studies of Commit.

What is Agitation?

Agitation (state of anxiety or nervous excitement) is found to be associated with 2,278 drugs and 3,304 conditions by eHealthMe. Check the latest studies of Agitation.

On May, 04, 2026

4,836 people reported to have side effects when taking Commit.
Among them, 11 people (0.23%) have Agitation.

Among these 11 people:

How long have people been on Commit when they have Agitation? *

What is the gender of people who have Agitation when taking Commit? *

female: 70 %
male: 30 %

What is the age of people who have Agitation when taking Commit? *

What are other drugs people take besides Commit? *

What are other side effects people have besides Agitation? *

Nervousness: 4 people, 36.36%
Insomnia (sleeplessness): 3 people, 27.27%
Stress And Anxiety: 3 people, 27.27%
Psychomotor Hyperactivity (feelings of extreme restlessness): 3 people, 27.27%
Heart Rate Increased: 2 people, 18.18%
Depression: 2 people, 18.18%
Nicotine Dependence: 2 people, 18.18%
Headache (pain in head): 1 person, 9.09%
Feeling Jittery: 1 person, 9.09%
Feeling Abnormal: 1 person, 9.09%

What are the existing conditions these people have? *

Quit Smoking: 3 people, 27.27%
Neuralgia (pain in one or more nerves): 1 person, 9.09%
Joint Pain: 1 person, 9.09%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Commit and have Agitation?

- Check whether Agitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Commit:

Commit (4,842 reports)

Agitation treatments and more:

Agitation (142,107 reports)

Browse all side effects of Commit:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agitation:

Agitation (2,278 drugs)

Browse all the conditions that are associated with Agitation:

Agitation (3,304 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on nicotine polacrilex (the active ingredients of Commit) and Commit (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.