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Compazine and Dry eyes - a phase IV clinical study of FDA data

Summary:

Dry eyes is reported as a side effect among people who take Compazine (prochlorperazine maleate), especially for people who are female, 60+ old, also take Zofran, and have Ovarian cancer.

The phase IV clinical study analyzes which people have Dry eyes when taking Compazine. It is created by eHealthMe based on reports of 13,599 people who have side effects when taking Compazine from the FDA, and is updated regularly.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

What is Dry eyes?

Dry eyes (lack of adequate tears) is found to be associated with 1,580 drugs and 2,053 conditions by eHealthMe. Check the latest studies of Dry eyes.

On Jul, 25, 2026

13,599 people reported to have side effects when taking Compazine.
Among them, 53 people (0.39%) have Dry eyes.

Could Compazine cause Dry eyes?

Among these 53 people:

What is the gender of people who have Dry eyes when taking Compazine? *

  • female: 78.43 %
  • male: 21.57 %

What is the age of people who have Dry eyes when taking Compazine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 5.56 %
  • 20-29: 0.0 %
  • 30-39: 2.78 %
  • 40-49: 11.11 %
  • 50-59: 22.22 %
  • 60+: 58.33 %

What are other drugs people take besides Compazine? *

  1. Zofran: 18 people, 33.96%
  2. Vitamin B12: 15 people, 28.30%
  3. Percocet: 14 people, 26.42%
  4. Zyrtec: 12 people, 22.64%
  5. Fish Oil: 12 people, 22.64%
  6. Vitamin D3: 12 people, 22.64%
  7. Tylenol: 11 people, 20.75%
  8. Flonase: 10 people, 18.87%
  9. Nexium: 10 people, 18.87%
  10. Calcium: 9 people, 16.98%

What are other side effects people have besides Dry eyes? *

  1. Fatigue (feeling of tiredness): 21 people, 39.62%
  2. Constipation: 20 people, 37.74%
  3. Rashes (redness): 15 people, 28.30%
  4. Vision Blurred: 14 people, 26.42%
  5. Diarrhea: 14 people, 26.42%
  6. Joint Pain: 13 people, 24.53%
  7. Back Pain: 13 people, 24.53%
  8. Weakness: 13 people, 24.53%
  9. Headache (pain in head): 12 people, 22.64%
  10. Anaemia (lack of blood): 12 people, 22.64%

What are the existing conditions these people have? *

  1. Pain: 7 people, 13.21%
  2. Multiple Myeloma (cancer of the plasma cells): 7 people, 13.21%
  3. Ovarian Cancer (cancer of ovary): 7 people, 13.21%
  4. Depression: 5 people, 9.43%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 7.55%
  6. Weight Decreased: 4 people, 7.55%
  7. Pain In Jaw: 4 people, 7.55%
  8. Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 4 people, 7.55%
  9. Hypersensitivity: 4 people, 7.55%
  10. Sleep Disorder: 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

Do you take Compazine and have Dry eyes?

- Check whether Dry eyes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Compazine:

Dry eyes treatments and more:

How severe was Dry eyes and when was it recovered:

Expand to all the drugs that have ingredients of prochlorperazine maleate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Compazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dry eyes:

Browse all the conditions that are associated with Dry eyes:

How the study uses the data?

The study uses data from the FDA. It is based on prochlorperazine maleate (the active ingredients of Compazine) and Compazine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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