Compazine and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Compazine (prochlorperazine maleate), especially for people who are female, 60+ old, also take Zofran, and have Immune system disorder.

The phase IV clinical study analyzes which people have Sciatica when taking Compazine. It is created by eHealthMe based on reports of 13,599 people who have side effects when taking Compazine from the FDA, and is updated regularly.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in nausea and vomiting. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,147 drugs and 1,426 conditions by eHealthMe. Check the latest studies of Sciatica.

On Feb, 21, 2026

13,599 people reported to have side effects when taking Compazine.
Among them, 31 people (0.23%) have Sciatica.

Among these 31 people:

What is the gender of people who have Sciatica when taking Compazine? *

female: 76.67 %
male: 23.33 %

What is the age of people who have Sciatica when taking Compazine? *

What are other drugs people take besides Compazine? *

What are other side effects people have besides Sciatica? *

Diarrhea: 18 people, 58.06%
Intervertebral Disc Protrusion (spinal disc protrusion): 15 people, 48.39%
Urinary Tract Infection: 12 people, 38.71%
Dehydration (dryness resulting from the removal of water): 12 people, 38.71%
Weakness: 11 people, 35.48%
Osteonecrosis Of Jaw (death of bone of jaw): 11 people, 35.48%
Pain: 11 people, 35.48%
Headache (pain in head): 11 people, 35.48%
White Blood Cell Count Increased: 10 people, 32.26%
Fatigue (feeling of tiredness): 10 people, 32.26%

What are the existing conditions these people have? *

Pain: 7 people, 22.58%
Immune System Disorder: 7 people, 22.58%
Muscle Spasms (muscle contraction): 6 people, 19.35%
Abdominal Discomfort: 5 people, 16.13%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 4 people, 12.90%
Cough: 4 people, 12.90%
Dry Eyes (lack of adequate tears): 4 people, 12.90%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 12.90%
Metastases To Bone (cancer spreads to bone): 4 people, 12.90%
Multiple Myeloma (cancer of the plasma cells): 4 people, 12.90%

* Approximation only. Some reports may have incomplete information.

Do you take Compazine and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Compazine:

Compazine (13,646 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

Browse all side effects of Compazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,147 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,426 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on prochlorperazine maleate (the active ingredients of Compazine) and Compazine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.