Comtan and Neck pain - a phase IV clinical study of FDA data

Summary:

Neck pain is reported as a side effect among people who take Comtan (entacapone), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Atarax, and have Depression.

The phase IV clinical study analyzes which people have Neck pain when taking Comtan. It is created by eHealthMe based on reports of 3,900 people who have side effects when taking Comtan from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Neck pain?

Neck pain is found to be associated with 2,073 drugs and 2,821 conditions by eHealthMe. Check the latest studies of Neck pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

3,900 people reported to have side effects when taking Comtan.
Among them, 23 people (0.59%) have Neck pain.

Among these 23 people:

How long have people been on Comtan when they have Neck pain? *

What is the gender of people who have Neck pain when taking Comtan? *

female: 52.17 %
male: 47.83 %

What is the age of people who have Neck pain when taking Comtan? *

What are other drugs people take besides Comtan? *

What are other side effects people have besides Neck pain? *

Back Pain: 15 people, 65.22%
Suicide Attempt: 13 people, 56.52%
Depression: 13 people, 56.52%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 12 people, 52.17%
Muscle Spasms (muscle contraction): 10 people, 43.48%
Chest Pain: 10 people, 43.48%
Tremor (trembling or shaking movements in one or more parts of your body): 9 people, 39.13%
Weight Increased: 8 people, 34.78%
Fall: 8 people, 34.78%
Nausea (feeling of having an urge to vomit): 8 people, 34.78%

What are the existing conditions these people have? *

Depression: 5 people, 21.74%
Dermal Cyst: 2 people, 8.70%
Rickets (softening of bones): 1 person, 4.35%
Ovarian Cancer (cancer of ovary): 1 person, 4.35%
Nausea And Vomiting: 1 person, 4.35%
Migraine (headache): 1 person, 4.35%
Inflammation: 1 person, 4.35%
High Blood Pressure: 1 person, 4.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 4.35%
Gastritis (inflammation of stomach): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Comtan and have Neck pain?

- Check whether Neck pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Comtan:

Comtan (3,979 reports)

Neck pain treatments and more:

Neck pain (83,325 reports)

Browse all side effects of Comtan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Neck pain:

Neck pain (2,073 drugs)

Browse all the conditions that are associated with Neck pain:

Neck pain (2,821 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on entacapone (the active ingredients of Comtan) and Comtan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.