Comtan and Neutrophil count increased - a phase IV clinical study of FDA data

Summary:

Neutrophil count increased is reported as a side effect among people who take Comtan (entacapone), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Clozaril, and have Schizophrenia.

The phase IV clinical study analyzes which people have Neutrophil count increased when taking Comtan. It is created by eHealthMe based on reports of 3,900 people who have side effects when taking Comtan from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Neutrophil count increased?

Neutrophil count increased (excess than normal number of neutrophil a type of blood cell) is found to be associated with 942 drugs and 1,168 conditions by eHealthMe. Check the latest studies of Neutrophil count increased.

On Aug, 01, 2026

3,900 people reported to have side effects when taking Comtan.
Among them, 14 people (0.36%) have Neutrophil count increased.

Could Comtan cause Neutrophil count increased?

Among these 14 people:

How long have people been on Comtan when they have Neutrophil count increased? *

What is the gender of people who have Neutrophil count increased when taking Comtan? *

female: 28.57 %
male: 71.43 %

What is the age of people who have Neutrophil count increased when taking Comtan? *

What are other drugs people take besides Comtan? *

Clozaril: 4 people, 28.57%
Pramipexole Dihydrochloride: 3 people, 21.43%
Carbidopa And Levodopa: 3 people, 21.43%
Cabergoline: 3 people, 21.43%
Slow-K: 1 person, 7.14%
Ramipril: 1 person, 7.14%
Prevacid: 1 person, 7.14%
Neupro: 1 person, 7.14%
Famotidine: 1 person, 7.14%
Clonazepam: 1 person, 7.14%

What are other side effects people have besides Neutrophil count increased? *

Blood Lactate Dehydrogenase Increased: 8 people, 57.14%
Nausea (feeling of having an urge to vomit): 7 people, 50.00%
Aspartate Aminotransferase Increased: 7 people, 50.00%
Mitral Valve Sclerosis (thickening and stiffness of the valve): 6 people, 42.86%
Protein Total Decreased: 6 people, 42.86%
Ventricular Hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do): 6 people, 42.86%
Tricuspid Valve Sclerosis (thickening of tricuspid valve): 6 people, 42.86%
Ejection Fraction Decreased (systolic heart failure): 6 people, 42.86%
Lymphocyte Count Decreased: 6 people, 42.86%
Blood Chloride Increased: 6 people, 42.86%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Comtan and have Neutrophil count increased?

- Check whether Neutrophil count increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Comtan:

Comtan (3,979 reports)

Browse all side effects of Comtan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Neutrophil count increased:

Neutrophil count increased (942 drugs)

Browse all the conditions that are associated with Neutrophil count increased:

Neutrophil count increased (1,168 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on entacapone (the active ingredients of Comtan) and Comtan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.