Comtan and Panic attack - a phase IV clinical study of FDA data

Summary:

Panic attack is reported as a side effect among people who take Comtan (entacapone), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Sinemet, and have Depression.

The phase IV clinical study analyzes which people have Panic attack when taking Comtan. It is created by eHealthMe based on reports of 3,900 people who have side effects when taking Comtan from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Panic attack?

Panic attack is found to be associated with 2,184 drugs and 2,082 conditions by eHealthMe. Check the latest studies of Panic attack.

On May, 27, 2026

3,900 people reported to have side effects when taking Comtan.
Among them, 19 people (0.49%) have Panic attack.

Among these 19 people:

How long have people been on Comtan when they have Panic attack? *

What is the gender of people who have Panic attack when taking Comtan? *

female: 52.63 %
male: 47.37 %

What is the age of people who have Panic attack when taking Comtan? *

What are other drugs people take besides Comtan? *

What are other side effects people have besides Panic attack? *

Stress And Anxiety: 12 people, 63.16%
Weakness: 8 people, 42.11%
Pain: 8 people, 42.11%
Pathological Gambling: 7 people, 36.84%
Drowsiness: 5 people, 26.32%
Psychiatric Symptom: 5 people, 26.32%
Mania (a state of abnormally elevated or irritable mood): 4 people, 21.05%
Libido Increased (increased sexual urge to have sex): 4 people, 21.05%
Libido Decreased (loss of interest in sex): 4 people, 21.05%
Judgement Impaired: 4 people, 21.05%

What are the existing conditions these people have? *

Depression: 7 people, 36.84%
Nausea (feeling of having an urge to vomit): 4 people, 21.05%
Compulsions (performing an act persistently and repetitively): 4 people, 21.05%
Stress And Anxiety: 3 people, 15.79%
Rapid Eye Movements Sleep Abnormal: 3 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%
Constipation: 3 people, 15.79%
Cardiac Failure Chronic: 3 people, 15.79%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 5.26%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Comtan and have Panic attack?

- Check whether Panic attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Comtan:

Comtan (3,979 reports)

Panic attack treatments and more:

Panic attack (65,704 reports)

Browse all side effects of Comtan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Panic attack:

Panic attack (2,184 drugs)

Browse all the conditions that are associated with Panic attack:

Panic attack (2,082 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on entacapone (the active ingredients of Comtan) and Comtan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.