Comtan and Suicide attempt - a phase IV clinical study of FDA data

Summary:

Suicide attempt is reported as a side effect among people who take Comtan (entacapone), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Effexor, and have Depression.

The phase IV clinical study analyzes which people have Suicide attempt when taking Comtan. It is created by eHealthMe based on reports of 3,900 people who have side effects when taking Comtan from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Suicide attempt?

Suicide attempt is found to be associated with 1,376 drugs and 1,492 conditions by eHealthMe. Check the latest studies of Suicide attempt.

On Jul, 12, 2026

3,900 people reported to have side effects when taking Comtan.
Among them, 41 people (1.05%) have Suicide attempt.

Among these 41 people:

How long have people been on Comtan when they have Suicide attempt? *

What is the gender of people who have Suicide attempt when taking Comtan? *

female: 60.98 %
male: 39.02 %

What is the age of people who have Suicide attempt when taking Comtan? *

What are other drugs people take besides Comtan? *

What are other side effects people have besides Suicide attempt? *

Depression: 18 people, 43.90%
Abnormal Behavior: 15 people, 36.59%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 14 people, 34.15%
Neck Pain: 13 people, 31.71%
Back Pain: 13 people, 31.71%
Weight Increased: 12 people, 29.27%
Compulsive Shopping: 12 people, 29.27%
Fall: 12 people, 29.27%
Pathological Gambling: 11 people, 26.83%
Dyspnea (difficult or laboured breathing): 10 people, 24.39%

What are the existing conditions these people have? *

Depression: 5 people, 12.20%
Dermal Cyst: 2 people, 4.88%
Depressive Symptom: 2 people, 4.88%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 2.44%
High Blood Pressure: 1 person, 2.44%
High Blood Cholesterol: 1 person, 2.44%
Feeling Of Relaxation: 1 person, 2.44%
Emotional Disorder: 1 person, 2.44%
Diabetes: 1 person, 2.44%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Comtan and have Suicide attempt?

- Check whether Suicide attempt is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Comtan:

Comtan (3,979 reports)

Suicide attempt treatments and more:

Suicide attempt (81,434 reports)

Browse all side effects of Comtan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Suicide attempt:

Suicide attempt (1,376 drugs)

Browse all the conditions that are associated with Suicide attempt:

Suicide attempt (1,492 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on entacapone (the active ingredients of Comtan) and Comtan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.