1. Home
  2. Analysis
  3. Concerta
  4. Negativism

Concerta and Negativism - a phase IV clinical study of FDA data

Summary:

Negativism is reported as a side effect among people who take Concerta (methylphenidate hydrochloride), especially for people who are male, 10-19 old, also take Strattera, and have Asperger's disorder.

The phase IV clinical study analyzes which people have Negativism when taking Concerta. It is created by eHealthMe based on reports of 20,995 people who have side effects when taking Concerta from the FDA, and is updated regularly.

What is Concerta?

Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 25,040 Concerta users. Check the latest studies of Concerta.

What is Negativism?

Negativism (negative thoughts) is found to be associated with 77 drugs and 234 conditions by eHealthMe. Check the latest studies of Negativism.

On Aug, 12, 2026

20,995 people reported to have side effects when taking Concerta.
Among them, 13 people (0.06%) have Negativism.

Could Concerta cause Negativism?

Among these 13 people:

What is the gender of people who have Negativism when taking Concerta? *

  • female: 8.33 %
  • male: 91.67 %

What is the age of people who have Negativism when taking Concerta? *

  • 0-1: 0.0 %
  • 2-9: 40 %
  • 10-19: 50 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Concerta? *

  1. Strattera: 8 people, 61.54%
  2. Methylphenidate: 2 people, 15.38%
  3. Paxil: 1 person, 7.69%
  4. Fluoxetine: 1 person, 7.69%

What are other side effects people have besides Negativism? *

  1. Aggression: 6 people, 46.15%
  2. Drug Ineffective: 4 people, 30.77%
  3. Abnormal Behavior: 3 people, 23.08%
  4. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 15.38%
  5. Disturbance In Attention: 2 people, 15.38%
  6. Irritability: 2 people, 15.38%
  7. Fatigue (feeling of tiredness): 1 person, 7.69%
  8. Anger: 1 person, 7.69%
  9. Apathy: 1 person, 7.69%
  10. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 1 person, 7.69%

What are the existing conditions these people have? *

  1. Asperger's Disorder (autism spectrum disorder that affects language and behavioural development in children): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Concerta and have Negativism?

- Check whether Negativism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Concerta:

Negativism treatments and more:

How severe was Negativism and when was it recovered:

Expand to all the drugs that have ingredients of methylphenidate hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Concerta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Negativism:

Browse all the conditions that are associated with Negativism:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Concerta) and Concerta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.