Cortef and Polyuria - a phase IV clinical study of FDA data

Summary:

Polyuria is reported as a side effect among people who take Cortef (hydrocortisone), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Synthroid, and have Hypopituitarism.

The phase IV clinical study analyzes which people have Polyuria when taking Cortef. It is created by eHealthMe based on reports of 4,132 people who have side effects when taking Cortef from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Polyuria?

Polyuria (production of too much dilute urine) is found to be associated with 1,655 drugs and 1,283 conditions by eHealthMe. Check the latest studies of Polyuria.

On Apr, 18, 2026

4,132 people reported to have side effects when taking Cortef.
Among them, 19 people (0.46%) have Polyuria.

Among these 19 people:

How long have people been on Cortef when they have Polyuria? *

What is the gender of people who have Polyuria when taking Cortef? *

female: 73.68 %
male: 26.32 %

What is the age of people who have Polyuria when taking Cortef? *

What are other drugs people take besides Cortef? *

What are other side effects people have besides Polyuria? *

Fatigue (feeling of tiredness): 14 people, 73.68%
Thirst - Excessive: 14 people, 73.68%
Spinal Osteoarthritis (joint cartilage loss in spine): 12 people, 63.16%
Diarrhea: 11 people, 57.89%
Paleness (unusual lightness of skin colour): 11 people, 57.89%
Joint Pain: 10 people, 52.63%
Pathological Fracture (broken bone caused by disease): 10 people, 52.63%
Periodontal Disease (disease that attacks the gum and bone and around the teeth): 10 people, 52.63%
Pain: 10 people, 52.63%
Osteopenia (a condition where bone mineral density is lower than normal): 10 people, 52.63%

What are the existing conditions these people have? *

Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 4 people, 21.05%
Osteoporosis (bones weak and more likely to break): 2 people, 10.53%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Cortef and have Polyuria?

- Check whether Polyuria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cortef:

Cortef (4,254 reports)

Polyuria treatments and more:

Polyuria (15,800 reports)

Browse all side effects of Cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polyuria:

Polyuria (1,655 drugs)

Browse all the conditions that are associated with Polyuria:

Polyuria (1,283 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone (the active ingredients of Cortef) and Cortef (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.