Cosopt and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Cosopt (dorzolamide hydrochloride; timolol maleate), especially for people who are female, 60+ old, also take Digoxin, and have Paget's disease.

The phase IV clinical study analyzes which people have Anhedonia when taking Cosopt. It is created by eHealthMe based on reports of 8,872 people who have side effects when taking Cosopt from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,506 drugs and 1,284 conditions by eHealthMe. Check the latest studies of Anhedonia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

8,872 people reported to have side effects when taking Cosopt.
Among them, 19 people (0.21%) have Anhedonia.

Among these 19 people:

What is the gender of people who have Anhedonia when taking Cosopt? *

female: 68.42 %
male: 31.58 %

What is the age of people who have Anhedonia when taking Cosopt? *

What are other drugs people take besides Cosopt? *

What are other side effects people have besides Anhedonia? *

Pain: 18 people, 94.74%
Stress And Anxiety: 18 people, 94.74%
Emotional Distress: 16 people, 84.21%
Injury: 13 people, 68.42%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 57.89%
Pneumonia: 11 people, 57.89%
Acute Kidney Failure: 11 people, 57.89%
Anaemia (lack of blood): 11 people, 57.89%
Cardiac Failure Congestive: 9 people, 47.37%
Fainting (loss of consciousness and postural tone): 8 people, 42.11%

What are the existing conditions these people have? *

Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 7 people, 36.84%
Hiv Infection: 6 people, 31.58%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 21.05%
Urinary Retention (the inability to completely or partially empty the bladder): 2 people, 10.53%
Erection Problems: 2 people, 10.53%
Bone Pain: 2 people, 10.53%
Deformity (disfigurement): 2 people, 10.53%
Depression: 2 people, 10.53%
Diabetes: 2 people, 10.53%
High Blood Cholesterol: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Cosopt and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cosopt:

Cosopt (9,029 reports)

Anhedonia treatments and more:

Anhedonia (51,944 reports)

How severe was Anhedonia and when was it recovered:

Anhedonia in Cosopt

Expand to all the drugs that have ingredients of dorzolamide hydrochloride; timolol maleate:

Anhedonia and drugs with ingredients of dorzolamide hydrochloride; timolol maleate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cosopt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,506 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,284 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dorzolamide hydrochloride; timolol maleate (the active ingredients of Cosopt) and Cosopt (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.