Cosopt and Drug intolerance - a phase IV clinical study of FDA data

Summary:

Drug intolerance is reported as a side effect among people who take Cosopt (dorzolamide hydrochloride; timolol maleate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Xalatan, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Drug intolerance when taking Cosopt. It is created by eHealthMe based on reports of 8,872 people who have side effects when taking Cosopt from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Drug intolerance?

Drug intolerance (drug sensitivity) is found to be associated with 1,906 drugs and 1,599 conditions by eHealthMe. Check the latest studies of Drug intolerance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

8,872 people reported to have side effects when taking Cosopt.
Among them, 51 people (0.57%) have Drug intolerance.

Among these 51 people:

How long have people been on Cosopt when they have Drug intolerance? *

What is the gender of people who have Drug intolerance when taking Cosopt? *

female: 78.72 %
male: 21.28 %

What is the age of people who have Drug intolerance when taking Cosopt? *

What are other drugs people take besides Cosopt? *

What are other side effects people have besides Drug intolerance? *

Drug Ineffective: 29 people, 56.86%
Drug Hypersensitivity: 26 people, 50.98%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 26 people, 50.98%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 25 people, 49.02%
Colitis Microscopic (inflammation of colon with diarrhoea and abdominal cramps): 25 people, 49.02%
Synovitis (inflammation of the synovial membrane): 21 people, 41.18%
C-Reactive Protein Increased: 18 people, 35.29%
High Blood Pressure: 16 people, 31.37%
Nausea And Vomiting: 16 people, 31.37%
Pneumonia: 16 people, 31.37%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 26 people, 50.98%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 9.80%
Renal Cell Carcinoma (a kidney cancer): 2 people, 3.92%
Intraocular Pressure Increased: 2 people, 3.92%
Constipation: 2 people, 3.92%
Vision Blurred: 1 person, 1.96%
Diabetes: 1 person, 1.96%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 1.96%
Cancer Pain: 1 person, 1.96%
Cardiac Failure Congestive: 1 person, 1.96%

* Approximation only. Some reports may have incomplete information.

Do you take Cosopt and have Drug intolerance?

- Check whether Drug intolerance is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cosopt:

Cosopt (9,029 reports)

Drug intolerance treatments and more:

Drug intolerance (103,988 reports)

How severe was Drug intolerance and when was it recovered:

Drug intolerance in Cosopt

Expand to all the drugs that have ingredients of dorzolamide hydrochloride; timolol maleate:

Drug intolerance and drugs with ingredients of dorzolamide hydrochloride; timolol maleate (298 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cosopt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug intolerance:

Drug intolerance (1,906 drugs)

Browse all the conditions that are associated with Drug intolerance:

Drug intolerance (1,599 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dorzolamide hydrochloride; timolol maleate (the active ingredients of Cosopt) and Cosopt (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.