Cosopt and Hot flushes aggravated - a phase IV clinical study of FDA data

Summary:

Hot flushes aggravated is reported as a side effect among people who take Cosopt (dorzolamide hydrochloride; timolol maleate), especially for people who are female, 60+ old, also take Xalatan, and have Cardiac murmur.

The phase IV clinical study analyzes which people have Hot flushes aggravated when taking Cosopt. It is created by eHealthMe based on reports of 8,872 people who have side effects when taking Cosopt from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Hot flushes aggravated?

Hot flushes aggravated (sudden feelings of heat) is found to be associated with 1,519 drugs and 475 conditions by eHealthMe. Check the latest studies of Hot flushes aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

8,872 people reported to have side effects when taking Cosopt.
Among them, 29 people (0.33%) have Hot flushes aggravated.

Could Cosopt cause Hot flushes aggravated?

Among these 29 people:

What is the gender of people who have Hot flushes aggravated when taking Cosopt? *

female: 82.76 %
male: 17.24 %

What is the age of people who have Hot flushes aggravated when taking Cosopt? *

What are other drugs people take besides Cosopt? *

What are other side effects people have besides Hot flushes aggravated? *

Headache (pain in head): 14 people, 48.28%
High Blood Pressure: 13 people, 44.83%
Drowsiness: 10 people, 34.48%
Nausea (feeling of having an urge to vomit): 10 people, 34.48%
Gait Disturbance: 9 people, 31.03%
Mobility Decreased (ability to move is reduced): 9 people, 31.03%
Chest Pain: 9 people, 31.03%
Nausea And Vomiting: 7 people, 24.14%
Cardiac Murmur (an heart sound in valve abnormality): 7 people, 24.14%
Feeling Cold: 7 people, 24.14%

What are the existing conditions these people have? *

Thyroid Diseases: 7 people, 24.14%
Cardiac Murmur (an heart sound in valve abnormality): 7 people, 24.14%
Pain In Extremity: 5 people, 17.24%
Neuroendocrine Tumor: 5 people, 17.24%
Multiple Allergies (allergy to multiple agents): 4 people, 13.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 13.79%
Prostate Cancer: 3 people, 10.34%
Nicotine Dependence: 3 people, 10.34%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 6.90%
Intracardiac Thrombus (presence of a circumscribed mass with heart wall): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Cosopt and have Hot flushes aggravated?

- Check whether Hot flushes aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cosopt:

Cosopt (9,029 reports)

Hot flushes aggravated treatments and more:

Hot flushes aggravated (49 reports)

How severe was Hot flushes aggravated and when was it recovered:

Hot flushes aggravated in Cosopt

Expand to all the drugs that have ingredients of dorzolamide hydrochloride; timolol maleate:

Hot flushes aggravated and drugs with ingredients of dorzolamide hydrochloride; timolol maleate (47 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cosopt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hot flushes aggravated:

Hot flushes aggravated (1,519 drugs)

Browse all the conditions that are associated with Hot flushes aggravated:

Hot flushes aggravated (475 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dorzolamide hydrochloride; timolol maleate (the active ingredients of Cosopt) and Cosopt (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.