Cotrim and Aphthous stomatitis - a phase IV clinical study of FDA data

Summary:

Aphthous stomatitis is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, also take Famvir, and have Chronic lymphocytic leukaemia.

The phase IV clinical study analyzes which people have Aphthous stomatitis when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Aphthous stomatitis?

Aphthous stomatitis (mouth ulcer) is found to be associated with 430 drugs and 811 conditions by eHealthMe. Check the latest studies of Aphthous stomatitis.

On Jul, 14, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 19 people (0.21%) have Aphthous stomatitis.

Among these 19 people:

What is the gender of people who have Aphthous stomatitis when taking Cotrim? *

female: 21.05 %
male: 78.95 %

What is the age of people who have Aphthous stomatitis when taking Cotrim? *

What are other drugs people take besides Cotrim? *

What are other side effects people have besides Aphthous stomatitis? *

Pain: 12 people, 63.16%
Neuropathy Peripheral (surface nerve damage): 7 people, 36.84%
Lung Infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 7 people, 36.84%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 36.84%
Bone Disorder: 7 people, 36.84%
Fungal Nail Infection: 7 people, 36.84%
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 7 people, 36.84%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 7 people, 36.84%
Cataract (clouding of the lens inside the eye): 7 people, 36.84%
Cellulitis (infection under the skin): 7 people, 36.84%

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 21.05%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 15.79%
High Blood Pressure: 3 people, 15.79%
Epstein-Barr Virus Associated Lymphoproliferative Disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Aphthous stomatitis?

- Check whether Aphthous stomatitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Aphthous stomatitis treatments and more:

Aphthous stomatitis (3,782 reports)

How severe was Aphthous stomatitis and when was it recovered:

Aphthous stomatitis in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Aphthous stomatitis and drugs with ingredients of sulfamethoxazole; trimethoprim (73 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aphthous stomatitis:

Aphthous stomatitis (430 drugs)

Browse all the conditions that are associated with Aphthous stomatitis:

Aphthous stomatitis (811 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.