Cotrim and Blood sodium increased - a phase IV clinical study of FDA data

Summary:

Blood sodium increased is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are male, 2-9 old, have been taking the drug for < 1 month also take Oxycodone, and have B-cell type acute leukaemia.

The phase IV clinical study analyzes which people have Blood sodium increased when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Blood sodium increased?

Blood sodium increased is found to be associated with 475 drugs and 638 conditions by eHealthMe. Check the latest studies of Blood sodium increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 11 people (0.12%) have Blood sodium increased.

Could Cotrim cause Blood sodium increased?

Among these 11 people:

How long have people been on Cotrim when they have Blood sodium increased? *

What is the gender of people who have Blood sodium increased when taking Cotrim? *

female: 9.09 %
male: 90.91 %

What is the age of people who have Blood sodium increased when taking Cotrim? *

What are other drugs people take besides Cotrim? *

Benadryl: 6 people, 54.55%
Oxycodone: 6 people, 54.55%
Acetaminophen: 2 people, 18.18%
Fluconazole: 2 people, 18.18%
Calcium Carbonate: 2 people, 18.18%
Cetirizine Hydrochloride: 2 people, 18.18%
Lidocaine: 2 people, 18.18%
Cyclophosphamide: 2 people, 18.18%
Diflucan: 1 person, 9.09%
Zidovudine: 1 person, 9.09%

What are other side effects people have besides Blood sodium increased? *

Haemoglobin Decreased: 9 people, 81.82%
Haematocrit Decreased: 8 people, 72.73%
Thrombocytopenia (decrease of platelets in blood): 8 people, 72.73%
Blood Potassium Decreased: 8 people, 72.73%
Red Blood Cell Count Decreased: 7 people, 63.64%
Fever: 7 people, 63.64%
Blood Chloride Increased: 7 people, 63.64%
White Blood Cell Count Increased: 7 people, 63.64%
Aspartate Aminotransferase Increased: 7 people, 63.64%
Mouth Haemorrhage (bleeding from mouth): 6 people, 54.55%

What are the existing conditions these people have? *

Pain: 6 people, 54.55%
Nausea (feeling of having an urge to vomit): 6 people, 54.55%
B-Cell Type Acute Leukaemia (cancer of the white blood cells): 6 people, 54.55%
Hiv Infection: 1 person, 9.09%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 1 person, 9.09%
Diarrhea: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Blood sodium increased?

- Check whether Blood sodium increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Blood sodium increased treatments and more:

Blood sodium increased (3,658 reports)

How severe was Blood sodium increased and when was it recovered:

Blood sodium increased in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Blood sodium increased and drugs with ingredients of sulfamethoxazole; trimethoprim

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Blood sodium increased:

Blood sodium increased (475 drugs)

Browse all the conditions that are associated with Blood sodium increased:

Blood sodium increased (638 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.