Cotrim and Cholangitis - a phase IV clinical study of FDA data

Summary:

Cholangitis is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Pantoprazole, and have Gastritis.

The phase IV clinical study analyzes which people have Cholangitis when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Cholangitis?

Cholangitis (infection of the bile duct) is found to be associated with 656 drugs and 749 conditions by eHealthMe. Check the latest studies of Cholangitis.

On Jul, 29, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 35 people (0.39%) have Cholangitis.

Among these 35 people:

How long have people been on Cotrim when they have Cholangitis? *

What is the gender of people who have Cholangitis when taking Cotrim? *

female: 2.94 %
male: 97.06 %

What is the age of people who have Cholangitis when taking Cotrim? *

What are other drugs people take besides Cotrim? *

Pantoprazole: 20 people, 57.14%
Kaletra: 19 people, 54.29%
Truvada: 19 people, 54.29%
Tivicay: 18 people, 51.43%
Piperacillin And Tazobactam: 13 people, 37.14%
Rocephin: 7 people, 20.00%
Acyclovir: 6 people, 17.14%
Ranitidine: 6 people, 17.14%
Zovirax: 5 people, 14.29%
Calciparine: 5 people, 14.29%

What are other side effects people have besides Cholangitis? *

Acute Kidney Failure: 26 people, 74.29%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 26 people, 74.29%
Hepatic Enzyme Increased: 26 people, 74.29%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 26 people, 74.29%
Hepatomegaly (abnormal enlargement of the liver): 25 people, 71.43%
Hepatitis (inflammation of the liver): 25 people, 71.43%
Fatigue (feeling of tiredness): 23 people, 65.71%
Weakness: 23 people, 65.71%
Hepatic Failure (liver failure): 23 people, 65.71%
Fever: 22 people, 62.86%

What are the existing conditions these people have? *

Gastritis (inflammation of stomach): 23 people, 65.71%
High Blood Pressure: 22 people, 62.86%
Hiv Infection: 21 people, 60.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 20 people, 57.14%
Oesophageal Candidiasis (fungal infection of oesophagus): 20 people, 57.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 20 people, 57.14%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 8.57%
Metastases To Bone (cancer spreads to bone): 2 people, 5.71%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 1 person, 2.86%
Autoimmune Hepatitis: 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Cholangitis?

- Check whether Cholangitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Cholangitis treatments and more:

Cholangitis (7,720 reports)

How severe was Cholangitis and when was it recovered:

Cholangitis in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Cholangitis and drugs with ingredients of sulfamethoxazole; trimethoprim (232 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cholangitis:

Cholangitis (656 drugs)

Browse all the conditions that are associated with Cholangitis:

Cholangitis (749 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.