Cotrim and Drug hypersensitivity - a phase IV clinical study of FDA data

Summary:

Drug hypersensitivity is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Nevirapine, and have Hiv infection.

The phase IV clinical study analyzes which people have Drug hypersensitivity when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Drug hypersensitivity?

Drug hypersensitivity is found to be associated with 2,482 drugs and 2,340 conditions by eHealthMe. Check the latest studies of Drug hypersensitivity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 79 people (0.89%) have Drug hypersensitivity.

Could Cotrim cause Drug hypersensitivity?

Among these 79 people:

How long have people been on Cotrim when they have Drug hypersensitivity? *

What is the gender of people who have Drug hypersensitivity when taking Cotrim? *

female: 51.28 %
male: 48.72 %

What is the age of people who have Drug hypersensitivity when taking Cotrim? *

What are other drugs people take besides Cotrim? *

What are other side effects people have besides Drug hypersensitivity? *

Fever: 38 people, 48.10%
Malaise (a feeling of general discomfort or uneasiness): 18 people, 22.78%
Nausea (feeling of having an urge to vomit): 18 people, 22.78%
Nausea And Vomiting: 17 people, 21.52%
Rashes (redness): 16 people, 20.25%
Urinary Tract Infection: 13 people, 16.46%
Fatigue (feeling of tiredness): 12 people, 15.19%
Hypotension (abnormally low blood pressure): 11 people, 13.92%
Sepsis (a severe blood infection that can lead to organ failure and death): 11 people, 13.92%
Itching: 10 people, 12.66%

What are the existing conditions these people have? *

Hiv Infection: 16 people, 20.25%
Urinary Tract Infection: 11 people, 13.92%
Ovarian Cancer (cancer of ovary): 8 people, 10.13%
Necrotising Retinitis (life threatening infection of retina): 5 people, 6.33%
Lower Respiratory Tract Infection: 5 people, 6.33%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 5 people, 6.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 3.80%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 2.53%
High Blood Pressure: 2 people, 2.53%
Iron Overload: 2 people, 2.53%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Drug hypersensitivity?

- Check whether Drug hypersensitivity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Drug hypersensitivity treatments and more:

Drug hypersensitivity (222,796 reports)

How severe was Drug hypersensitivity and when was it recovered:

Drug hypersensitivity in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Drug hypersensitivity and drugs with ingredients of sulfamethoxazole; trimethoprim (6,470 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug hypersensitivity:

Drug hypersensitivity (2,482 drugs)

Browse all the conditions that are associated with Drug hypersensitivity:

Drug hypersensitivity (2,340 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.