Cotrim and Nephrolithiasis - a phase IV clinical study of FDA data

Summary:

Nephrolithiasis is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Prednisone, and have Fungal infection.

The phase IV clinical study analyzes which people have Nephrolithiasis when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Nephrolithiasis?

Nephrolithiasis (calculi in the kidneys) is found to be associated with 2,655 drugs and 2,141 conditions by eHealthMe. Check the latest studies of Nephrolithiasis.

On Jun, 15, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 19 people (0.21%) have Nephrolithiasis.

Among these 19 people:

How long have people been on Cotrim when they have Nephrolithiasis? *

What is the gender of people who have Nephrolithiasis when taking Cotrim? *

female: 36.84 %
male: 63.16 %

What is the age of people who have Nephrolithiasis when taking Cotrim? *

What are other drugs people take besides Cotrim? *

What are other side effects people have besides Nephrolithiasis? *

Hyperlipidaemia (presence of excess lipids in the blood): 8 people, 42.11%
Pneumonia: 8 people, 42.11%
Diabetes: 8 people, 42.11%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 42.11%
Stress And Anxiety: 8 people, 42.11%
Osteosclerosis (an elevation in bone density): 7 people, 36.84%
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 7 people, 36.84%
Otitis Media (inflammation of the middle ear): 7 people, 36.84%
Osteoporosis (bones weak and more likely to break): 7 people, 36.84%
Osteonecrosis Of Jaw (death of bone of jaw): 7 people, 36.84%

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 15.79%
Fungal Infection: 3 people, 15.79%
Vulvovaginal Candidiasis (vulvovaginal infection by fungi): 2 people, 10.53%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 10.53%
Tonsillitis (inflammation of tonsil): 2 people, 10.53%
Rickets (softening of bones): 2 people, 10.53%
Kidney Infection (Pyelonephritis): 2 people, 10.53%
Iron Deficiency: 2 people, 10.53%
Birth Control: 2 people, 10.53%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Nephrolithiasis?

- Check whether Nephrolithiasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Nephrolithiasis treatments and more:

Nephrolithiasis (59,727 reports)

How severe was Nephrolithiasis and when was it recovered:

Nephrolithiasis in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Nephrolithiasis and drugs with ingredients of sulfamethoxazole; trimethoprim (677 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nephrolithiasis:

Nephrolithiasis (2,655 drugs)

Browse all the conditions that are associated with Nephrolithiasis:

Nephrolithiasis (2,141 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.