Cotrim and Non-a or non-b hepatitis - a phase IV clinical study of FDA data

Summary:

Non-a or non-b hepatitis is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Prednisolone, and have High blood pressure.

The phase IV clinical study analyzes which people have Non-a or non-b hepatitis when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Non-a or non-b hepatitis?

Non-a or non-b hepatitis (liver infection without a or b hepatitis type) is found to be associated with 1,240 drugs and 984 conditions by eHealthMe. Check the latest studies of Non-a or non-b hepatitis.

On Jun, 17, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 8 people (0.09%) have Non-a or non-b hepatitis.

Could Cotrim cause Non-a or non-b hepatitis?

Among these 8 people:

How long have people been on Cotrim when they have Non-a or non-b hepatitis? *

What is the gender of people who have Non-a or non-b hepatitis when taking Cotrim? *

female: 87.5 %
male: 12.5 %

What is the age of people who have Non-a or non-b hepatitis when taking Cotrim? *

What are other drugs people take besides Cotrim? *

Heparin: 3 people, 37.50%
Aldactone: 3 people, 37.50%
Prednisolone: 3 people, 37.50%
Levofloxacin: 2 people, 25.00%
Meropenem: 2 people, 25.00%
Levothyroxine Sodium: 2 people, 25.00%
Lasix: 2 people, 25.00%
Lamisil: 2 people, 25.00%
Intal: 2 people, 25.00%
Hydrocortisone Butyrate: 2 people, 25.00%

What are other side effects people have besides Non-a or non-b hepatitis? *

Thrombocytopenia (decrease of platelets in blood): 3 people, 37.50%
Fever: 3 people, 37.50%
Multi-Organ Failure (multisystem organ failure): 2 people, 25.00%
Ascites (accumulation of fluid in the abdominal cavity): 2 people, 25.00%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 2 people, 25.00%
Cellulitis (infection under the skin): 2 people, 25.00%
Drug Eruption (adverse drug reaction of the skin): 2 people, 25.00%
Histiocytosis Haematophagic: 2 people, 25.00%
Infection: 2 people, 25.00%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 2 people, 25.00%

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 37.50%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 25.00%
Osteodystrophy (a dystrophic growth of the bone): 2 people, 25.00%
Insomnia (sleeplessness): 2 people, 25.00%
Immunodeficiency Disorders: 2 people, 25.00%
Pneumonia: 1 person, 12.50%
Hypotension (abnormally low blood pressure): 1 person, 12.50%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 1 person, 12.50%
Gastric Ulcer (stomach ulcer): 1 person, 12.50%
Essential Hypertension (primary hypertension): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Non-a or non-b hepatitis?

- Check whether Non-a or non-b hepatitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Non-a or non-b hepatitis treatments and more:

Non-a or non-b hepatitis (131,813 reports)

How severe was Non-a or non-b hepatitis and when was it recovered:

Non-a or non-b hepatitis in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Non-a or non-b hepatitis and drugs with ingredients of sulfamethoxazole; trimethoprim (196 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Non-a or non-b hepatitis:

Non-a or non-b hepatitis (1,240 drugs)

Browse all the conditions that are associated with Non-a or non-b hepatitis:

Non-a or non-b hepatitis (984 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.