Cotrim and Septic shock - a phase IV clinical study of FDA data

Summary:

Septic shock is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Vancomycin, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Septic shock when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Septic shock?

Septic shock (shock due to blood infection) is found to be associated with 1,728 drugs and 3,400 conditions by eHealthMe. Check the latest studies of Septic shock.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 82 people (0.92%) have Septic shock.

Among these 82 people:

How long have people been on Cotrim when they have Septic shock? *

What is the gender of people who have Septic shock when taking Cotrim? *

female: 38.75 %
male: 61.25 %

What is the age of people who have Septic shock when taking Cotrim? *

What are other drugs people take besides Cotrim? *

What are other side effects people have besides Septic shock? *

Acute Kidney Failure: 21 people, 25.61%
Pneumonia: 20 people, 24.39%
Multi-Organ Failure (multisystem organ failure): 19 people, 23.17%
Fever: 16 people, 19.51%
Thrombocytopenia (decrease of platelets in blood): 15 people, 18.29%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 14 people, 17.07%
Leukopenia (less number of white blood cells in blood): 12 people, 14.63%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 12 people, 14.63%
Anaemia (lack of blood): 11 people, 13.41%
Hypotension (abnormally low blood pressure): 10 people, 12.20%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 12.20%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 9.76%
Sepsis (a severe blood infection that can lead to organ failure and death): 6 people, 7.32%
High Blood Pressure: 6 people, 7.32%
Stress And Anxiety: 5 people, 6.10%
Cytomegalovirus Infection: 5 people, 6.10%
Chronic Lymphocytic Leukaemia Recurrent (repeated cancer of blood cells known as lymphocytes): 5 people, 6.10%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.10%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 6.10%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 4.88%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Septic shock?

- Check whether Septic shock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Septic shock treatments and more:

Septic shock (51,128 reports)

How severe was Septic shock and when was it recovered:

Septic shock in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Septic shock and drugs with ingredients of sulfamethoxazole; trimethoprim (1,992 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Septic shock:

Septic shock (1,728 drugs)

Browse all the conditions that are associated with Septic shock:

Septic shock (3,400 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.