Coumadin and Application site pruritus - a phase IV clinical study of FDA data

Summary:

Application site pruritus is reported as a side effect among people who take Coumadin (warfarin sodium), especially for people who are female, 60+ old, also take Adcirca, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Application site pruritus when taking Coumadin. It is created by eHealthMe based on reports of 128,882 people who have side effects when taking Coumadin from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Application site pruritus?

Application site pruritus (application site severe itching of the skin) is found to be associated with 549 drugs and 910 conditions by eHealthMe. Check the latest studies of Application site pruritus.

On Jul, 13, 2026

128,882 people reported to have side effects when taking Coumadin.
Among them, 83 people (0.06%) have Application site pruritus.

Could Coumadin cause Application site pruritus?

Among these 83 people:

What is the gender of people who have Application site pruritus when taking Coumadin? *

female: 87.8 %
male: 12.2 %

What is the age of people who have Application site pruritus when taking Coumadin? *

What are other drugs people take besides Coumadin? *

What are other side effects people have besides Application site pruritus? *

Application Site Erythema (redness of the skin at application site): 32 people, 38.55%
Catheter Site Erythema (redness of skin at catheter site): 26 people, 31.33%
Diarrhea: 24 people, 28.92%
Application Site Rash: 21 people, 25.30%
Nausea (feeling of having an urge to vomit): 20 people, 24.10%
Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 20 people, 24.10%
Dyspnea (difficult or laboured breathing): 20 people, 24.10%
Headache (pain in head): 19 people, 22.89%
Catheter Site Pruritus (itching at the site): 17 people, 20.48%
Skin Blushing/flushing (a sudden reddening of the face, neck): 16 people, 19.28%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 35 people, 42.17%
High Blood Pressure: 13 people, 15.66%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 12 people, 14.46%
Cardiac Disorder: 4 people, 4.82%
Pain: 4 people, 4.82%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 3 people, 3.61%
High Blood Cholesterol: 3 people, 3.61%
Blood Pressure Abnormal: 3 people, 3.61%
Breakthrough Pain: 2 people, 2.41%
Depression: 2 people, 2.41%

* Approximation only. Some reports may have incomplete information.

Do you take Coumadin and have Application site pruritus?

- Check whether Application site pruritus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Coumadin:

Coumadin (133,228 reports)

Browse all side effects of Coumadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site pruritus:

Application site pruritus (549 drugs)

Browse all the conditions that are associated with Application site pruritus:

Application site pruritus (910 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on warfarin sodium (the active ingredients of Coumadin) and Coumadin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.