Coumadin and Diverticular perforation - a phase IV clinical study of FDA data

Summary:

Diverticular perforation is reported as a side effect among people who take Coumadin (warfarin sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Restoril, and have Insomnia.

The phase IV clinical study analyzes which people have Diverticular perforation when taking Coumadin. It is created by eHealthMe based on reports of 128,882 people who have side effects when taking Coumadin from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Diverticular perforation?

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated) is found to be associated with 362 drugs and 413 conditions by eHealthMe. Check the latest studies of Diverticular perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

128,882 people reported to have side effects when taking Coumadin.
Among them, 35 people (0.03%) have Diverticular perforation.

Could Coumadin cause Diverticular perforation?

Among these 35 people:

How long have people been on Coumadin when they have Diverticular perforation? *

What is the gender of people who have Diverticular perforation when taking Coumadin? *

female: 61.76 %
male: 38.24 %

What is the age of people who have Diverticular perforation when taking Coumadin? *

What are other drugs people take besides Coumadin? *

What are other side effects people have besides Diverticular perforation? *

Constipation: 12 people, 34.29%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 6 people, 17.14%
Fever: 5 people, 14.29%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 5 people, 14.29%
Urination - Painful: 5 people, 14.29%
Duodenal Ulcer Perforation (untreated ulcer can burn through the wall of the stomach): 5 people, 14.29%
Pitting Oedema (skin discoloration): 5 people, 14.29%
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 5 people, 14.29%
Hypotension (abnormally low blood pressure): 5 people, 14.29%
Activated Partial Thromboplastin Time Prolonged: 4 people, 11.43%

What are the existing conditions these people have? *

Insomnia (sleeplessness): 6 people, 17.14%
Infection: 5 people, 14.29%
Lung Cancer - Non-Small Cell (lung cancer): 5 people, 14.29%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 5 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.29%
High Blood Pressure: 5 people, 14.29%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 14.29%
Pain: 5 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 4 people, 11.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.43%

* Approximation only. Some reports may have incomplete information.

Do you take Coumadin and have Diverticular perforation?

- Check whether Diverticular perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Coumadin:

Coumadin (133,228 reports)

Browse all side effects of Coumadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diverticular perforation:

Diverticular perforation (362 drugs)

Browse all the conditions that are associated with Diverticular perforation:

Diverticular perforation (413 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on warfarin sodium (the active ingredients of Coumadin) and Coumadin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.