Coumadin and Sinus arrhythmia - a phase IV clinical study of FDA data

Summary:

Sinus arrhythmia is reported as a side effect among people who take Coumadin (warfarin sodium), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Sinus arrhythmia when taking Coumadin. It is created by eHealthMe based on reports of 128,882 people who have side effects when taking Coumadin from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Sinus arrhythmia?

Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle) is found to be associated with 360 drugs and 419 conditions by eHealthMe. Check the latest studies of Sinus arrhythmia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

128,882 people reported to have side effects when taking Coumadin.
Among them, 77 people (0.06%) have Sinus arrhythmia.

Among these 77 people:

How long have people been on Coumadin when they have Sinus arrhythmia? *

What is the gender of people who have Sinus arrhythmia when taking Coumadin? *

female: 33.78 %
male: 66.22 %

What is the age of people who have Sinus arrhythmia when taking Coumadin? *

What are other drugs people take besides Coumadin? *

What are other side effects people have besides Sinus arrhythmia? *

Pain: 44 people, 57.14%
Stress And Anxiety: 41 people, 53.25%
Dyspnea (difficult or laboured breathing): 41 people, 53.25%
Back Pain: 40 people, 51.95%
Diarrhea: 37 people, 48.05%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 34 people, 44.16%
Cardiac Failure Congestive: 33 people, 42.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 33 people, 42.86%
Chest Pain: 32 people, 41.56%
Osteonecrosis Of Jaw (death of bone of jaw): 31 people, 40.26%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 36 people, 46.75%
Joint Pain: 5 people, 6.49%
Depression: 5 people, 6.49%
Pain: 5 people, 6.49%
Breast Cancer Metastatic: 4 people, 5.19%
High Blood Cholesterol: 4 people, 5.19%
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls): 3 people, 3.90%
Blood Uric Acid Increased: 3 people, 3.90%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 3.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 3.90%

* Approximation only. Some reports may have incomplete information.

Do you take Coumadin and have Sinus arrhythmia?

- Check whether Sinus arrhythmia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Coumadin:

Coumadin (133,228 reports)

Browse all side effects of Coumadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus arrhythmia:

Sinus arrhythmia (360 drugs)

Browse all the conditions that are associated with Sinus arrhythmia:

Sinus arrhythmia (419 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on warfarin sodium (the active ingredients of Coumadin) and Coumadin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.