Coumadin and Small intestinal perforation - a phase IV clinical study of FDA data

Summary:

Small intestinal perforation is reported as a side effect among people who take Coumadin (warfarin sodium), especially for people who are male, 60+ old, also take Pentasa, and have Crohn's disease.

The phase IV clinical study analyzes which people have Small intestinal perforation when taking Coumadin. It is created by eHealthMe based on reports of 128,882 people who have side effects when taking Coumadin from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Small intestinal perforation?

Small intestinal perforation (hole in small intestine) is found to be associated with 232 drugs and 424 conditions by eHealthMe. Check the latest studies of Small intestinal perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

128,882 people reported to have side effects when taking Coumadin.
Among them, 18 people (0.01%) have Small intestinal perforation.

Could Coumadin cause Small intestinal perforation?

Among these 18 people:

What is the gender of people who have Small intestinal perforation when taking Coumadin? *

female: 31.25 %
male: 68.75 %

What is the age of people who have Small intestinal perforation when taking Coumadin? *

What are other drugs people take besides Coumadin? *

What are other side effects people have besides Small intestinal perforation? *

White Blood Cell Count Increased: 6 people, 33.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 33.33%
Post Procedural Complication: 5 people, 27.78%
Small Intestinal Obstruction (blockage in small intestine): 5 people, 27.78%
Gastrointestinal Anastomotic Leak (breakdown at the site of a post-surgical closure of a stomach and intestine): 4 people, 22.22%
Muscle Atrophy (a decrease in the mass of the muscle): 4 people, 22.22%
Drug Ineffective: 4 people, 22.22%
Electrical Burn: 4 people, 22.22%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 4 people, 22.22%
Lump In The Abdomen (an area of swelling or growth on abdomen): 4 people, 22.22%

What are the existing conditions these people have? *

Intestinal Obstruction: 4 people, 22.22%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 22.22%
Vena Cava Thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart): 3 people, 16.67%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 3 people, 16.67%
Hypercoagulation (increased tendency for clotting of the blood): 3 people, 16.67%
Postoperative Ileus: 1 person, 5.56%
Gout (uric acid crystals building up in the body): 1 person, 5.56%
Back Pain: 1 person, 5.56%
Blood Count Abnormal: 1 person, 5.56%
Cardiac Disorder: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Coumadin and have Small intestinal perforation?

- Check whether Small intestinal perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Coumadin:

Coumadin (133,228 reports)

Browse all side effects of Coumadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Small intestinal perforation:

Small intestinal perforation (232 drugs)

Browse all the conditions that are associated with Small intestinal perforation:

Small intestinal perforation (424 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on warfarin sodium (the active ingredients of Coumadin) and Coumadin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.